Publications de Veronika Rackayová

Age Dependence of Neurometabolic Changes in a Rat Pup Model of Type C Hepatic Encephalopathy

Cristina Ramona Cudalbu, Veronika Rackayová, Dunja Simicic

Lippincott Williams & Wilkins2023

Neurometabolic changes in a rat pup model of type C hepatic encephalopathy depend on age at liver disease onset

Cristina Ramona Cudalbu, Veronika Rackayová, Dunja Simicic

Chronic liver disease (CLD) is a serious condition where various toxins present in the blood affect the brain leading to type C hepatic encephalopathy (HE). Both adults and children are impacted, while children may display unique vulnerabilities depending ...

SPRINGER/PLENUM PUBLISHERS2023

Late post‐natal neurometabolic development in healthy male rats using 1 H and 31 P Magnetic Resonance Spectroscopy

Rolf Gruetter, Cristina Ramona Cudalbu, Veronika Rackayová, Guillaume Donati, Dunja Simicic

Brain metabolism evolves rapidly during early post‐natal development in the rat. While changes in amino acids, energy metabolites, antioxidants or metabolites involved in phospholipid metabolism have been reported in the early stages, neurometabolic change ...

2021

In vivo macromolecule signals in rat brain 1 H‐MR spectra at 9.4T: Parametrization, spline baseline estimation, and T 2 relaxation times

Lijing Xin, Cristina Ramona Cudalbu, Bernard Lanz, Veronika Rackayová, Dunja Simicic

Purpose Reliable detection and fitting of macromolecules (MM) are crucial for accurate quantification of brain short-echo time (TE) 1H-MR spectra. An experimentally acquired single MM spectrum is commonly used. Higher spectral resolution at ultra-high fiel ...

Wiley2021

Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease

Cristina Ramona Cudalbu, Jocelin Grosse, Veronika Rackayová, Emmanuelle Ines Flatt

Chronic liver disease leads to neuropsychiatric complications called hepatic encephalopathy (HE). Current treatments have some limitations in their efficacy and tolerability, emphasizing the need for alternative therapies. Modulation of gut bacterial flora ...

Nature Research2021

Longitudinal osmotic and neurometabolic changes in young rats with chronic cholestatic liver disease

Cristina Ramona Cudalbu, Veronika Rackayová

Type C hepatic encephalopathy (type C HE) is increasingly suspected in children with chronic liver disease (CLD), and believed to underlie long-term neurocognitive difficulties. The molecular underpinnings of type C HE in both adults and children are incom ...

Nature Research2020

Contribution of macromolecules to brain H-1 MR spectra: Experts' consensus recommendations

Rolf Gruetter, Lijing Xin, Cristina Ramona Cudalbu, Hongxia Lei, Veronika Rackayová, Dunja Simicic

Proton MR spectra of the brain, especially those measured at short and intermediate echo times, contain signals from mobile macromolecules (MM). A description of the main MM is provided in this consensus paper. These broad peaks of MM underlie the narrower ...

WILEY2020

In Vivo Longitudinal 1H MRS Study of Hippocampal, Cereberal and Striatal Metabolic Changes in the Adult Brain Using an Animal Model of Chronic Hepatic Encephalopathy

Cristina Ramona Cudalbu, Katarzyna Pierzchala, Veronika Rackayová, Dario Sessa, Dunja Simicic, Stefanita-Octavian Mitrea

LIPPINCOTT WILLIAMS & WILKINS2019

Brain Regional Susceptibility to Oxidative Stress in a Rat Model of Chronic Hepatic Encephalopathy: In-Vivo 1H MRS, Ex-Vivo ESR Spectroscopy and Histology Findings

Rolf Gruetter, Cristina Ramona Cudalbu, Andrzej Sienkiewicz, Katarzyna Pierzchala, Veronika Rackayová, Dario Sessa, Dunja Simicic

LIPPINCOTT WILLIAMS & WILKINS2019

Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy

Cristina Ramona Cudalbu, Katarzyna Pierzchala, Jocelin Grosse, Veronika Rackayová

Background & Aims: The sequence of events in hepatic encephalopathy (HE) remains unclear. Using the advantages of in vivo 1H-MRS (9.4T) we aimed to analyse the time-course of disease in an established model of type C HE by analysing the longitudinal change ...

2019