Publications de Christian Hammer

The influence of human genetic variation on Epstein–Barr virus sequence diversity

Jacques Fellay, Olivier Noël Marie Naret, Christian Hammer, Dylan Lawless, Sina Rüeger

Epstein–Barr virus (EBV) is one of the most common viruses latently infecting humans. Little is known about the impact of human genetic variation on the large inter-individual differences observed in response to EBV infection. To search for a potential imp ...

Nature Research2021

Human genomics of the humoral immune response against polyomaviruses

Jacques Fellay, Christian Axel Wandall Thorball, Olivier Noël Marie Naret, Christian Hammer, Flavia Aurelia Shoko Hodel, Zhi Ming Xu, Petar Scepanovic

Human polyomaviruses are widespread in humans and can cause severe disease in immunocompromised individuals. To identify human genetic determinants of the humoral immune response against polyomaviruses, we performed genome-wide association studies and meta ...

OXFORD UNIV PRESS2021

Genetic variation near CXCL12 is associated with susceptibility to HIV-related non-Hodgkin lymphoma

Jacques Fellay, Christian Axel Wandall Thorball, Christian Hammer

Human immunodeficiency virus (HIV) infection is associated with an increased risk of non-Hodgkin lymphoma (NHL). Even in the era of suppressive antiretroviral treatment, HIV-infected individuals remain at higher risk of developing NHL compared to the gener ...

FERRATA STORTI FOUNDATION2021

Human genomics of the humoral response against polyomaviruses

Jacques Fellay, Christian Axel Wandall Thorball, Christian Hammer, Flavia Aurelia Shoko Hodel, Zhi Ming Xu, Petar Scepanovic

SPRINGERNATURE2020

Impact of Genetic and Nongenetic Factors on Body Mass Index and Waist-Hip Ratio Change in HIV-Infected Individuals Initiating Antiretroviral Therapy

Jacques Fellay, Christian Hammer, Christian Axel Wandall Thorball, Monia Guidi, Thierry Buclin

Objective. There is limited data on abdominal obesity and the influence of genetics on weight change after ant iretroviral therapy (ART) initiation. We assessed body mass index (BMI) and waist hip ration (WHR) change over time in the Swiss HIV Cohort study ...

OXFORD UNIV PRESS INC2020

HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

Jacques Fellay, Christian Hammer, Daniel Sauter

Many viral pathogens target innate sensing cascades and/or cellular transcription factors to suppress antiviral immune responses. Here, we show that the accessory viral protein U (Vpu) of HIV-1 exerts broad immunosuppressive effects by inhibiting activatio ...

2019

A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals

Jacques Fellay, Christian Hammer, Flavia Aurelia Shoko Hodel, Petar Scepanovic

Background The gut microbiome is an important determinant of human health. Its composition has been shown to be influenced by multiple environmental factors and likely by host genetic variation. In the framework of the Milieu Interieur Consortium, a total ...

2019

Genome-to-genome analysis of Epstein-Barr virus infection

Jacques Fellay, Christian Hammer

NATURE PUBLISHING GROUP2019

Human genomics of acute liver failure due to hepatitis B virus infection: An exome sequencing study in liver transplant recipients

Jacques Fellay, Christian Hammer, Nimisha Chaturvedi, Petar Scepanovic, Samira Asgari

Acute liver failure (ALF) or fulminant hepatitis is a rare, yet severe outcome of infection with hepatitis B virus (HBV) that carries a high mortality rate. The occurrence of a life-threatening condition upon infection with a prevalent virus in individuals ...

2019

Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines

Jacques Fellay, Petar Scepanovic, Christian Axel Wandall Thorball, Christian Hammer, Flavia Aurelia Shoko Hodel, Nimisha Chaturvedi

2018