Publications de Helen Rebecca Ostlund Farrants

Chemogenetic Control of Nanobodies

Kai Johnsson, Julien Hiblot, Helen Rebecca Ostlund Farrants

Engineered nanobody allows reversible control of activity in cells through the binding of small molecules. ...

NATURE PUBLISHING GROUP2020

Allosteric Protein Switches based on Antibody Mimetics

Synthetic protein switches are proteins that can be controlled by an external input, and are useful tools to probe protein function. Antibody fragments and antibody mimetics can be selected to bind, activate, or inhibit several diverse protein targets. Nev ...

EPFL2019

SNAP-Tagged Nanobodies Enable Reversible Optical Control of a G Protein-Coupled Receptor via a Remotely Tethered Photoswitchable Ligand

Kai Johnsson, Johannes Broichhagen, Helen Rebecca Ostlund Farrants

G protein-coupled receptors (GPCRs) mediate the transduction of extracellular signals into complex intracellular responses. Despite their ubiquitous roles in physiological processes and as drug targets for a wide range of disorders, the precise mechanisms ...

AMER CHEMICAL SOC2018

Modulating protein-protein interaction with a molecular tether

Kai Johnsson, Oliver Hantschel, Helen Rebecca Ostlund Farrants

Wiley-Blackwell2015