Publications de Michele Migliore

Community-based reconstruction and simulation of a full-scale model of region CA1 of rat hippocampus

Henry Markram, Eilif Benjamin Muller, Srikanth Ramaswamy, Michael Reimann, James Gonzalo King, Lida Kanari, Ying Shi, Armando Romani, Davide Bella, Felix Schürmann

The CA1 region of the hippocampus is one of the most studied regions of the rodent brain, thought to play an important role in cognitive functions such as memory and spatial navigation. Despite a wealth of experimental data on its structure and function, i ...

2024

Online interoperable resources for building hippocampal neuron models via the Hippocampus Hub

Armando Romani, Felix Schürmann, Michele Migliore, Luca Leonardo Bologna

To build biophysically detailed models of brain cells, circuits, and regions, a data-driven approach is increasingly being adopted. This helps to obtain a simulated activity that reproduces the experimentally recorded neural dynamics as faithfully as possi ...

2023

Different responses of mice and rats hippocampus CA1 pyramidal neurons to in vitro and in vivo-like inputs

Ying Shi, Armando Romani, Maurizio Ferdinando Pezzoli, Michele Migliore, Rosanna Migliore

The fundamental role of any neuron within a network is to transform complex spatiotemporal synaptic input patterns into individual output spikes. These spikes, in turn, act as inputs for other neurons in the network. Neurons must execute this function acro ...

2023

Reconstruction of the Hippocampus

Henry Markram, Armando Romani, Felix Schürmann, Michele Migliore

The hippocampus is a widely studied brain region thought to play an important role in higher cognitive functions such as learning, memory, and navigation. The amount of data on this region increases every day and delineates a complex and fragmented picture ...

Springer2022

The EBRAINS Hodgkin-Huxley Neuron Builder: An online resource for building data-driven neuron models

Jean-Denis Georges Emile Courcol, Michele Migliore, Genrich Ivaska, Carmen Alina Lupascu, Luca Leonardo Bologna, Shailesh Appukuttan

In the last decades, brain modeling has been established as a fundamental tool for understanding neural mechanisms and information processing in individual cells and circuits at different scales of observation. Building data-driven brain models requires th ...

FRONTIERS MEDIA SA2022

Data-driven integration of hippocampal CA1 synaptic physiology in silico

Eilif Benjamin Muller, Srikanth Ramaswamy, Michael Reimann, Armando Romani, András Ecker, Michele Migliore, Szabolcs Kali, Sàra Sàray, Audrey Mercer

The anatomy and physiology of monosynaptic connections in rodent hippocampal CA1 have been extensively studied in recent decades. Yet, the resulting knowledge remains disparate and difficult to reconcile. Here, we present a data-driven approach to integrat ...

2020

The Scientific Case for Brain Simulations

Felix Schürmann, Michele Migliore, Alain Destexhe

A key element of the European Union's Human Brain Project (HBP) and other large-scale brain research projects is the simulation of large-scale model networks of neurons. Here, we argue why such simulations will likely be indispensable for bridging the scal ...

CELL PRESS2019

The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow

Henry Markram, Eilif Benjamin Muller, Ying Shi, Armando Romani, Felix Schürmann, Jean-Denis Georges Emile Courcol, Werner Alfons Hilda Van Geit, Christian Andreas Rössert, Maurizio Ferdinando Pezzoli, Michele Migliore

Every neuron is part of a network, exerting its function by transforming multiple spatiotemporal synaptic input patterns into a single spiking output. This function is specified by the particular shape and passive electrical properties of the neuronal memb ...

2018