Publications de Wanze Chen | EPFL Graph Search

Live-seq enables temporal transcriptomic recording of single cells

Bart Deplancke, Vincent Roland Julien Gardeux, Riccardo Dainese, Orane Josiane Guillaume-Gentil, Wanze Chen, Pernille Yde Rainer, Magda Zachara, Wouter Saelens

Single-cell transcriptomics (scRNA-seq) has greatly advanced our ability to characterize cellular heterogeneity(1). However, scRNA-seq requires lysing cells, which impedes further molecular or functional analyses on the same cells. Here, we established Liv ...

NATURE PORTFOLIO2022

Postnatal expansion of mesenteric lymph node stromal cells towards reticular and CD34(+) stromal cell subsets

Bart Deplancke, Vincent Roland Julien Gardeux, Julie Marie Russeil, Jörn Pezoldt, Guido Van Mierlo, Maria Litovchenko, Wanze Chen, Marjan Biocanin

Gut-draining mesenteric lymph nodes (LN) provide the framework to shape intestinal adaptive immune responses. Based on the transcriptional signatures established by our previous work, the composition and immunomodulatory function of LN stromal cells (SC) v ...

Nature Portfolio2022

ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer

Didier Trono, Bart Deplancke, Julien Léonard Duc, Julie Marie Russeil, Riccardo Dainese, Marco Cassano, Michaël Imbeault, Sunil Kumar Raghav, Petra Catalina Schwalie, Suk Min Jang

Krüppel-associated box zinc finger proteins (KZFPs) constitute the largest family of mammalian transcription factors, but most remain completely uncharacterized. While initially proposed to primarily repress transposable elements, recent reports have revea ...

Nature Research2019

Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation

Bart Deplancke, Fei Zhang, Petra Catalina Schwalie, Wanze Chen

Cell Press2018

Ubiquitin-Specific Protease USP6 Regulates the Stability of the c-Jun Protein

Heena Yang, Wanze Chen

2018

Dissecting the brown adipogenic regulatory network using integrative genomics

Bart Deplancke, Wanze Chen, Vincent Roland Julien Gardeux, Julie Marie Russeil, Johannes Julius Bues, Daniel Alpern, Sunil Kumar Raghav, Petra Catalina Schwalie, Rachana Narendra Pradhan

Brown adipocytes regulate energy expenditure via mitochondrial uncoupling, which makes them attractive therapeutic targets to tackle obesity. However, the regulatory mechanisms underlying brown adipogenesis are still poorly understood. To address this, we ...

Springer Nature2017

Profiling of Single-Cell Transcriptomes

Bart Deplancke, Vincent Roland Julien Gardeux, Antonio Carlos Alves Meireles Filho, Wanze Chen

Complex biological systems are composed of multiple cell types whose transcriptional activity can vary due to differences in cell state, environmental stimulation or intrinsic programs. Conventional bulk analysis methods capture the average transcriptional ...

2017