Publications de Peyman Karami | EPFL Graph Search

Cartilage Repair: Promise of Adhesive Orthopedic Hydrogels

Dominique Pioletti, Peyman Karami, Lee Ann Laurent-Applegate

Cartilage repair remains a major challenge in human orthopedic medicine, necessitating the application of innovative strategies to overcome existing technical and clinical limitations. Adhesive hydrogels have emerged as promising candidates for cartilage r ...

MDPI2024

Wet adhesive hydrogels to correct malacic trachea (tracheomalacia) A proof of concept

Dominique Pioletti, Nikolaos Stergiopoulos, Peyman Karami, Sokratis Anagnostopoulos, Ece Uslu, Vijay Kumar Rana

Tracheomalacia (TM) is a condition characterized by a weak tracheal cartilage and/or muscle, resulting in excessive collapse of the airway in the newborns. Current treatments including tracheal reconstruction, tracheoplasty, endo- and extra-luminal stents ...

CELL PRESS2023

Mimicking Loading-Induced Cartilage Self-Heating in Vitro Promotes Matrix Formation in Chondrocyte-Laden Constructs with Different Mechanical Properties

Dominique Pioletti, Peyman Karami, Naser Nasrollahzadeh Mamaghani, Theofanis Stampoultzis, Yanheng Guo

Articular cartilage presents a mechanically sensitive tissue. Chondrocytes, the sole cell type residing in the tissue, perceive and react to physical cues as signals that significantly modulate their behavior. Hyaline cartilage is a connective tissue with ...

2023

Unraveling cartilage degeneration through synergistic effects of hydrostatic pressure and biomimetic temperature increase

Dominique Pioletti, Peyman Karami, Naser Nasrollahzadeh Mamaghani, Theofanis Stampoultzis, Yanheng Guo, Vijay Kumar Rana

Cartilage degeneration, typically viewed as an irreversible, vicious cycle, sees a significant reduction in two essential biophysical cues: the well-established hydrostatic pressure (HP) and the recently discovered transient temperature increase. Our study ...

Cell Press2023

A guide to preclinical evaluation of hydrogel-based devices for treatment of cartilage lesions

Dominique Pioletti, Peyman Karami, Theofanis Stampoultzis, Yanheng Guo

The drive to develop cartilage implants for the treatment of major defects in the musculoskeletal sys-tem has resulted in a major research thrust towards developing biomaterial devices for cartilage repair. Investigational devices for the restoration of ar ...

ELSEVIER SCI LTD2023

Temperature evolution following joint loading promotes chondrogenesis by synergistic cues via calcium signaling

Dominique Pioletti, Peyman Karami, Naser Nasrollahzadeh Mamaghani, Yanheng Guo, Jian Wang

During loading of viscoelastic tissues, part of the mechanical energy is transformed into heat that can locally increase the tissue temperature, a phenomenon known as self-heating. In the framework of mechanobiology, it has been accepted that cells react a ...

eLIFE SCIENCES PUBL LTD2022

NIR Light-Mediated Photocuring of Adhesive Hydrogels for Noninvasive Tissue Repair via Upconversion Optogenesis

Dominique Pioletti, Christophe Moser, Peyman Karami, Yanheng Guo, Antoine Vincent Boniface, Vijay Kumar Rana

The surgical treatments of injured soft tissues lead to further injury due to the use of sutures or the surgical routes, which need to be large enough to insert biomaterials for repair. In contrast, the use of low viscosity photopolymerizable hydrogels tha ...

American Chemical Society2022

An Injectable Family Of Soft Tissue Hydrogel Adhesives For Knee Applications

Dominique Pioletti, Pierre-Etienne Bourban, Christophe Moser, Peyman Karami, Céline Samira Wyss

MARY ANN LIEBERT, INC2022

Thoughts on cartilage tissue engineering: A 21st century perspective

Dominique Pioletti, Peyman Karami, Theofanis Stampoultzis

In mature individuals, hyaline cartilage demonstrates a poor intrinsic capacity for repair, thus even minor defects could result in progressive degeneration, impeding quality of life. Although numerous attempts have been made over the past years for the ad ...

2021

An Intrinsically-Adhesive Family of Injectable and Photo-Curable Hydrogels with Functional Physicochemical Performance for Regenerative Medicine

Dominique Pioletti, Pierre-Etienne Bourban, Christophe Moser, Peyman Karami, Naser Nasrollahzadeh Mamaghani, Céline Samira Wyss

Attaching hydrogels to soft internal tissues is crucial for the development of various biomedical devices. Tough sticky hydrogel patches present high adhesion, yet with lack of injectability and the need for treatment of contacting surface. On the contrary ...

WILEY-V C H VERLAG GMBH2021