Publications de Andreas Rowald

Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice

Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Léonie Asboth, Ileana Ozana Jelescu, Ivan Furfaro, Kyungjin Kim, Jérôme Gandar, Frédéric Pierre Gérald Michoud, Claudia Kathe

Optoelectronic systems can exert precise control over targeted neurons and pathways throughout the brain in untethered animals, but similar technologies for the spinal cord are not well established. In the present study, we describe a system for ultrafast, ...

NATURE PORTFOLIO2022

Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

Dimitri Nestor Alice Van De Ville, Silvestro Micera, Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Léonie Asboth, Robin Jonathan Demesmaeker, Nawal Noëlle Kinany, Miroslav Caban, Sergio Daniel Hernandez

Epidural electrical stimulation (EES) targeting the dorsal roots of lumbosacral segments restores walking in people with spinal cord injury (SCI). However, EES is delivered with multielectrode paddle leads that were originally designed to target the dorsal ...

NATURE PORTFOLIO2022

The neurons that restore walking after paralysis

Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Jordan Squair, Léonie Asboth, Katia Galan, Robin Jonathan Demesmaeker, Nicholas David James, Matthieu Pierre Gautier

A spinal cord injury interrupts pathways from the brain and brainstem that project to the lumbar spinal cord, leading to paralysis. Here we show that spatiotemporal epidural electrical stimulation (EES) of the lumbar spinal cord(1-3) applied during neurore ...

NATURE PORTFOLIO2022

Personalizable computational models of electrical spinal cord stimulation to restore function after neurological disorders

Andreas Rowald

Spinal Cord Injury (SCI) disrupts the communication between the brain and spinal circuits below the lesion, leading to a plethora of neurological impairments, including the loss of motor function. At present, the only medical practices to enhance recovery ...

EPFL2021

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Eduardo Martin Moraud, Quentin Barraud, Jordan Squair, Giuseppe Schiavone, Ileana Ozana Jelescu, Mark Andrew Anderson, Robin Jonathan Demesmaeker

Spinal cord injury (SCI) induces haemodynamic instability that threatens survival(1-3), impairs neurological recovery(4,5), increases the risk of cardiovascular disease(6,7), and reduces quality of life(8,9). Haemodynamic instability in this context is due ...

NATURE RESEARCH2021

Soft, Implantable Bioelectronic Interfaces for Translational Research

Stéphanie Lacour, Grégoire Courtine, Giuseppe Schiavone, Jocelyne Bloch, Ismael Seanez Gonzalez, Sébastien Jiguet, Ivan Furfaro, Simon Borgognon, Evgenia Vladimirova Roussinova, Marco Capogrosso

The convergence of materials science, electronics, and biology, namely bioelectronic interfaces, leads novel and precise communication with biological tissue, particularly with the nervous system. However, the translation of lab‐based innovation toward cli ...

Wiley2020

Targeted neurotechnology restores walking in humans with spinal cord injury

Grégoire Courtine, Jocelyne Bloch, Joachim von Zitzewitz, Vincent Delattre, Robin Jonathan Demesmaeker, Esra Neufeld, Miroslav Caban, Anne Marie Lucienne Watrin, Roman Heimgartner, Edoardo Paoles

2018

Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury

Silvestro Micera, Grégoire Courtine, Marco Capogrosso, Fabien Bertrand Paul Wagner, Jocelyne Bloch, Jean-Baptiste Mignardot, Emanuele Formento, Karen Minassian, Andreas Rowald, Camille Georgette Marie Le Goff-Mignardot

Epidural electrical stimulation (EES) of the spinal cord restores locomotion in animal models of spinal cord injury but is less effective in humans. Here we hypothesized that this interspecies discrepancy is due to interference between EES and propriocepti ...

2018