Personne
Erik Mailand
Cette personne n’est plus à l’EPFL
Publications associées (7)
Deconstructing body axis morphogenesis in zebrafish embryos using robot-assisted tissue micromanipulation
Andrew Charles Oates, Mahmut Selman Sakar, Ece Özelçi, Erik Mailand, Matthias Rüegg
Classic microsurgical techniques, such as those used in the early 1900s by Mangold and Spemann, have been instrumental in advancing our understanding of embryonic development. However, these techniques are highly specialized, leading to issues of inter-ope ...
2022Tissue Engineering with Mechanically Induced Solid‐Fluid Transitions
Mahmut Selman Sakar, Ece Özelçi, Jaemin Kim, Erik Mailand, Nikolaos Bouklas, Matthias Rüegg, Jon Märki, Odysseas Konstantinos Chaliotis
Epithelia are contiguous sheets of cells that stabilize the shape of internal organs and support their structure by covering their surfaces. They acquire diverse morphological forms appropriate for their specific functions during embryonic development, suc ...
2021Mechanical principles of engineering fibrous tissues with programmable shape
The form and structure of biological tissues define their function. The emergence of tissue morphology during development is one of the wonders of nature. Cells mechanically probe and manipulate their surroundings while constructing structures from the ext ...
EPFL2021Engineered Extracellular Matrices with Integrated Wireless Microactuators to Study Mechanobiology
Mahmut Selman Sakar, Erik Mailand, Nikolaos Bouklas, Fazil Emre Uslu
Mechanobiology explores how forces regulate cell behaviors and what molecular machinery are responsible for the sensing, transduction, and modulation of mechanical cues. To this end, probing of cells cultured on planar substrates has served as a primary ex ...
2021A model for 3D deformation and reconstruction of contractile microtissues
Mahmut Selman Sakar, Jaemin Kim, Erik Mailand, Nikolaos Bouklas
Tissue morphogenesis and regeneration are essentially mechanical processes that involve coordination of cellular forces, production and structural remodeling of extracellular matrix (ECM), and cell migration. Discovering the principles of cell–ECM interact ...
2020Surface and bulk stresses drive morphological changes in fibrous microtissues
Mahmut Selman Sakar, Erik Mailand, Nikolaos Bouklas
Engineered fibrous tissues consisting of cells encapsulated within collagen gels are widely used three-dimensional (3D) in vitro models of morphogenesis and wound healing. While cell-mediated matrix remodeling that occurs within these scaffolds has been ex ...
2019Complete inclusion of bioactive molecules and particles in polydimethylsiloxane: a straightforward process under mild conditions
Erik Mailand, Alice Cont, Elaheh Zare Eelanjegh, René M. Rossi
By applying a slow curing process, we show that biomolecules can be incorporated via a simple process as liquid stable phases inside a polydimethylsiloxane (PDMS) matrix. The process is carried out under mild conditions with regards to temperature, pH and ...
Springer2019