Publications de Maartje Martina Cornelia Bastings

Stimuli-Responsive Oligolysine-PEG Coatings for Reductive-Triggered Decomplexation

Maartje Martina Cornelia Bastings, Hugo José Rodriguez Franco

DNA origami nanoparticles (DONs) hold great potential for interacting with biological systems, yet their applicability is limited by nuclease activity and challenging ionic conditions in biological environments. Among various stabilization strategies, olig ...

American Chemical Society (ACS)2025

Multivalent Presentation of TCRs on DNA Nanostructures as a Sensitive Probe for pMHC Detection

Maartje Martina Cornelia Bastings, Kaltrina Paloja, Hugo José Rodriguez Franco

Dendritic cells (DCs) are key regulators of immune responses, presenting antigen-derived peptides on major histocompatibility complexes (pMHCs) to T cells for recognition via their T cell receptors (TCRs). Despite the weak intrinsic affinity of the TCR-pMH ...

American Chemical Society (ACS)2025

Interface flexibility controls the nucleation and growth of supramolecular networks

Georg Fantner, Maartje Martina Cornelia Bastings, Navid Asmari Saadabad, Cem Tekin, Veronika Cencen, Vincenzo Caroprese

Supramolecular networks are abundantly present in nature and, like crystalline materials, often develop from an initial nucleation site, followed by growth based on directional interactions between components. Traditionally, the binding strength and direct ...

2025

Spatial and stoichiometric in situ analysis of biomolecular oligomerization at single-protein resolution

Maartje Martina Cornelia Bastings

Latest advances in super-resolution microscopy allow the study of subcellular features at the level of single proteins, which could lead to discoveries in fundamental biological processes, specifically in cell signaling mediated by membrane receptors. Desp ...

Springer Science and Business Media LLC2025

Evolution of multivalent supramolecular assemblies of aptamers with target-defined spatial organization

Maartje Martina Cornelia Bastings, Yoan Désiré Duhoo, Cem Tekin, Vincenzo Caroprese

Rapid identification of neutralizing molecules against new and mutating viruses is key to efficiently combating biorisk. Current binder identification techniques use a monovalent library of potential binders. Interestingly, proteins on pathogens are often ...

2025

Dynamic Surface Interactions Enable the Self-Assembly of Perfect Supramolecular Crystals

Maartje Martina Cornelia Bastings, Cem Tekin, Vincenzo Caroprese

Supramolecular crystals arise from noncovalent interactions between macromonomers and allow for the engineering of dynamic functional materials. For two-dimensional (2D) crystals, the substrate surface can induce the formation of new polymorphs not availab ...

2024

The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects

Maartje Martina Cornelia Bastings

Peripheral CD8+ T cell tolerance is a checkpoint in both autoimmune disease and anti-cancer immunity. Despite its importance, the relationship between tolerance-induced states and other CD8+ T cell differentiation states remains unclear. Using flow cytomet ...

2024

Tailoring DNA Origami Protection: A Study of Oligolysine-PEG Coatings for Improved Colloidal, Structural, and Functional Integrity

Maartje Martina Cornelia Bastings

Application of protective polymer coatings to enhance the biostability of DNA-based nanomaterials (DONs) has become common practice in in vitro and in vivo experiments. While the functional effect of these coatings is obvious, a detailed molecular picture ...

2024

High-Speed Atomic Force Microscopy Imaging of DNA Three-Point-Star Motif Self Assembly Using Photothermal Off-Resonance Tapping

Georg Fantner, Maartje Martina Cornelia Bastings, Bahareh Ghadiani, Marcos Penedo Garcia, Santiago Harald Andany, Cem Tekin, Mustafa Kangül, Veronika Cencen

High-speed atomic force microscopy (HS-AFM) is a popular molecular imaging technique for visualizing single-molecule biological processes in real-time due to its ability to image under physiological conditions in liquid environments. The photothermal off-r ...

Journal Of Visualized Experiments2024

Modulating the DNA/Lipid Interface through Multivalent Hydrophobicity

Maartje Martina Cornelia Bastings, Diana Kornelia Morzy, Vincenzo Caroprese

Lipids and nucleic acids are two of the most abundant components of our cells, and both molecules are widely used as engineering materials for nanoparticles. Here, we present a systematic study of how hydrophobic modifications can be employed to modulate t ...

American Chemical Society (ACS)2024