Publications de Arin Can Ülkü

Beneath the surface: revealing deep-tissue blood flow in human subjects with massively parallelized diffuse correlation spectroscopy

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü, Michael Alan Wayne

Significance: Diffuse correlation spectroscopy (DCS) allows label-free, non-invasive investigation of microvascular dynamics deep within tissue, such as cerebral blood flow (CBF). However, the signal-to-noise ratio (SNR) in DCS limits its effective cerebra ...

SPIE-Intl Soc Optical Eng2025

Subsurface fluorescence time-of-flight imaging using a large-format single-photon avalanche diode sensor for tumor depth assessment

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü, Yichen Feng

Significance: Fluorescence guidance is used clinically by surgeons to visualize anatomical and/or physiological phenomena in the surgical field that are difficult or impossible to detect by the naked eye. Such phenomena include tissue perfusion or molecula ...

SPIE Society of Photo-optical Instrumentation Engineers2024

SwissSPAD2/3: a family of natively digital, time gated SPAD cameras with continuous streaming at up to 100 kpfs and picosecond system-level synchronization for quantum imaging applications

Edoardo Charbon, Claudio Bruschini, Andrei Ardelean, Paul Mos, Arin Can Ülkü

The SwissSPAD2/3 camera family is based on quarter megapixel single-photon avalanche diode (SPAD) time gated imagers. The 16.38-µm low-noise pixels feature a single-bit memory and built-in all-solid-state nanosecond time gating without the need for externa ...

SPIE2024

Temporal Point Spread Function Deconvolution in Time-resolved Fluorescence Lifetime Imaging using Deep Learning Model

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü

We report a deep RNN model for temporal point spread function (TPSFs) deconvolution in multimodal imaging systems to extract true sample fluorescence decay rate. It’s performance has been validated in phantom and well-plate data. ...

Optical Society of America2024

Deep learning-based temporal deconvolution for photon time-of-flight distribution retrieval

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü

The acquisition of the time of flight (ToF) of photons has found numerous applications in the biomedical field. Over the last decades, a few strategies have been proposed to deconvolve the temporal instrument response function (IRF) that distorts the exper ...

2024

GPU-based data processing for speeding-up correlation plenoptic imaging

Edoardo Charbon, Claudio Bruschini, Paul Mos, Samuel Burri, Arin Can Ülkü, Michael Alan Wayne

Correlation plenoptic imaging (CPI) is a novel technological imaging modality enabling to overcome drawbacks of standard plenoptic devices, while preserving their advantages. However, a major challenge in view of real-time application of CPI is related to ...

2024

Time-resolved Laser Speckle Contrast Imaging (TR-LSCI) of Cerebral Blood Flow

Edoardo Charbon, Claudio Bruschini, Paul Mos, Arin Can Ülkü

To address many of the deficiencies in optical neuroimaging technologies, such as poor tempo-spatial resolution, low penetration depth, contact-based measurement, and time-consuming image reconstruction, a novel, noncontact, portable, time-resolved laser s ...

Institute of Electrical and Electronics Engineers2024

3D fluorescence molecular tomography utilizing a novel SPAD camera

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü, Vikash Kumar Pandey

3D Fluorescence Molecular Tomography (FMT) is an important pre-clinical tool for quantifying and characterizing molecular markers for different diseases. Herein, we demonstrate, for the first time, 3D K-Space FMT reconstructions using a large time-gated SP ...

SPIE2024

Heralded Spectroscopy: a new single-particle probe for nanocrystal photophysics

Edoardo Charbon, Claudio Bruschini, Ivan Michel Antolovic, Samuel Burri, Arin Can Ülkü

Semiconductor nanocrystals feature multiply-excited states that display intriguing physics and significantly impact nanocrystal-based technologies. Fluorescence supplies a natural probe to investigate these states. Still, direct observation of multiexciton ...

SPIE2023

Correlated-photon imaging at 10 volumetric images per second

Edoardo Charbon, Claudio Bruschini, Paul Mos, Arin Can Ülkü

The correlation properties of light provide an outstanding tool to overcome the limitations of traditional imaging techniques. A relevant case is represented by correlation plenoptic imaging (CPI), a quantum-inspired volumetric imaging protocol employing s ...

Nature Portfolio2023