Publications de Dunja Simicic | EPFL Graph Search

Fast High-Resolution Metabolite Mapping in the rat Brain Using 1H-FID-MRSI at 14.1 T

Cristina Ramona Cudalbu, Bernard Lanz, Thanh Phong Kevin Lê, Jessie Julie Mosso, Dunja Simicic

Magnetic resonance spectroscopic imaging (MRSI) enables the simultaneous noninvasive acquisition of MR spectra from multiple spatial locations inside the brain. Although 1H-MRSI is increasingly used in the human brain, it is not yet widely applied in the p ...

2025

Heterozygous females from a rat model for creatine transporter deficiency reveal altered behavioral response to stressors, normal body weight and slight metabolic changes

Maria del Carmen Sandi Perez, Cristina Ramona Cudalbu, Dunja Simicic

Creatine (Cr) is an organic acid essential for recycling ATP, important in tissues with high energy demand such as muscle or brain. Cr is synthesized in a 2-step pathway by the enzymes AGAT and GAMT, and transported by SLC6A8 (also called CrT). Cerebral Cr ...

2025

Diffusion of brain metabolites highlights altered brain microstructure in type C hepatic encephalopathy: a 9.4 T preliminary study

Cristina Ramona Cudalbu, Katarzyna Pierzchala, Jessie Julie Mosso, Dunja Simicic

Introduction Type C hepatic encephalopathy (HE) is a decompensating event of chronic liver disease leading to severe motor and cognitive impairment. The progression of type C HE is associated with changes in brain metabolite concentrations measured by 1H m ...

Frontiers Media Sa2024

Noise-reduction techniques for 1H-FID-MRSI at 14.1 T: Monte Carlo validation and in vivo application

Cristina Ramona Cudalbu, Bernard Lanz, Thanh Phong Kevin Lê, Jessie Julie Mosso, Dunja Simicic

Proton magnetic resonance spectroscopic imaging (1H-MRSI) is a powerful tool that enables the multidimensional non-invasive mapping of the neurochemical profile at high resolution over the entire brain. The constant demand for higher spatial resolution in ...

Wiley2024

Inhibition of urease-mediated ammonia production by 2-octynohydroxamic acid in hepatic encephalopathy

Cristina Ramona Cudalbu, Katarzyna Pierzchala, Dunja Simicic, Stefanita-Octavian Mitrea

Hepatic encephalopathy is a neuropsychiatric complication of liver disease which is partly associated with elevated ammonemia. Urea hydrolysis by urease-producing bacteria in the colon is often mentioned as one of the main routes of ammonia production in t ...

Nature Portfolio2024

Brain Regional Differences in the Developing Brain Using an Animal Model of Type C Hepatic Encephalopathy

Cristina Ramona Cudalbu, Katarzyna Pierzchala, Dunja Simicic, Stefanita-Octavian Mitrea

Lippincott Williams & Wilkins2023

The Beneficial Effect of Oral Cr Supplementation in an Early Childhood Rat Model of Chronic Hepatic Encephalopathy: In Vivo Longitudinal 1H and 31P Magnetic Resonance Spectroscopy Study

Cristina Ramona Cudalbu, Katarzyna Pierzchala, Dunja Simicic, Stefanita-Octavian Mitrea

Lippincott Williams & Wilkins2023

Central Nervous System Oxidative Stress interplay with inflammation in a rat model of Type C Hepatic Encephalopathy - brothers in arms?

Cristina Ramona Cudalbu, Andrzej Sienkiewicz, Katarzyna Pierzchala, Dunja Simicic, Stefanita-Octavian Mitrea

ELSEVIER SCIENCE INC2023

Evaluation of a Hydroxamate-Based Urease Inhibitor in a Rodent Model of Hepatic Encephalopathy

Cristina Ramona Cudalbu, Katarzyna Pierzchala, Dunja Simicic, Stefanita-Octavian Mitrea

Lippincott Williams & Wilkins2023

Neurometabolic profiles of bile duct ligated rats after the treatment with an urease inhibitor – 1H MRS dataset

Cristina Ramona Cudalbu, Dunja Simicic

1H MRS in the cerebellum was used to study the effect of 2-octynohydroxamic acid (2-octynoHA) treatment on the brain of bile duct ligated (BDL) rats (type C hepatic encephalopathy). The study included four groups of rats: negative control group (rats recei ...

Zenodo2023