Publications de Hugo José Rodriguez Franco

Stimuli-Responsive Oligolysine-PEG Coatings for Reductive-Triggered Decomplexation

Maartje Martina Cornelia Bastings, Hugo José Rodriguez Franco

DNA origami nanoparticles (DONs) hold great potential for interacting with biological systems, yet their applicability is limited by nuclease activity and challenging ionic conditions in biological environments. Among various stabilization strategies, olig ...

American Chemical Society (ACS)2025

Mapping the Operative Space for Polymer-Biostabilized DNA Origami

Hugo José Rodriguez Franco

DNA origami nanoparticles (DONs) offer a powerful platform for interfacing with biological systems due to their precise structural programmability and molecular addressability. However, their performance is highly dependent on their stability and interacti ...

EPFL2025

Multivalent Presentation of TCRs on DNA Nanostructures as a Sensitive Probe for pMHC Detection

Maartje Martina Cornelia Bastings, Kaltrina Paloja, Hugo José Rodriguez Franco

Dendritic cells (DCs) are key regulators of immune responses, presenting antigen-derived peptides on major histocompatibility complexes (pMHCs) to T cells for recognition via their T cell receptors (TCRs). Despite the weak intrinsic affinity of the TCR-pMH ...

American Chemical Society (ACS)2025

Stabilizing Polymer Coatings Alter the Protein Corona of DNA Origami and Can Be Engineered to Bias the Cellular Uptake

Maartje Martina Cornelia Bastings, Hugo José Rodriguez Franco, Jorieke Weiden

With DNA-based nanomaterials being designed for applicationsincellular environments, the need arises to accurately understand theirsurface interactions toward biological targets. As for any materialexposed to protein-rich cell culture conditions, a protein ...

AMER CHEMICAL SOC2023

Strategic Insights into Engineering Parameters Affecting Cell Type-Specific Uptake of DNA-Based Nanomaterials

Maartje Martina Cornelia Bastings, Alice Comberlato, Hugo José Rodriguez Franco, Marianna Mainardi Koga

DNA-based nanomaterials are gaining popularity as uniform and programmable bioengineering tools as a result of recent solutions to their weak stability under biological conditions. The DNA nanotechnology platform uniquely allows decoupling of engineering p ...

American Chemical Society2022