Publications de Jessie Julie Mosso

Fast High-Resolution Metabolite Mapping in the rat Brain Using 1H-FID-MRSI at 14.1 T

Cristina Ramona Cudalbu, Bernard Lanz, Thanh Phong Kevin Lê, Jessie Julie Mosso, Dunja Simicic

Magnetic resonance spectroscopic imaging (MRSI) enables the simultaneous noninvasive acquisition of MR spectra from multiple spatial locations inside the brain. Although 1H-MRSI is increasingly used in the human brain, it is not yet widely applied in the p ...

2025

Ex vivo brain MRI to assess conventional and FLASH brain irradiation effects

Bernard Lanz, Jessie Julie Mosso

Background and purpose: The FLASH effect expands the therapeutic ratio of tumor control to normal tissue toxicity observed after delivery of ultra-high (>100 Gy/s FLASH-RT) vs. conventional dose rate radiation (CONV-RT). In this first exploratory study, we ...

2025

Diffusion of brain metabolites highlights altered brain microstructure in type C hepatic encephalopathy: a 9.4 T preliminary study

Cristina Ramona Cudalbu, Katarzyna Pierzchala, Jessie Julie Mosso, Dunja Simicic

Introduction Type C hepatic encephalopathy (HE) is a decompensating event of chronic liver disease leading to severe motor and cognitive impairment. The progression of type C HE is associated with changes in brain metabolite concentrations measured by 1H m ...

Frontiers Media Sa2024

Noise-reduction techniques for 1H-FID-MRSI at 14.1 T: Monte Carlo validation and in vivo application

Cristina Ramona Cudalbu, Bernard Lanz, Thanh Phong Kevin Lê, Jessie Julie Mosso, Dunja Simicic

Proton magnetic resonance spectroscopic imaging (1H-MRSI) is a powerful tool that enables the multidimensional non-invasive mapping of the neurochemical profile at high resolution over the entire brain. The constant demand for higher spatial resolution in ...

Wiley2024

New insights into rodent brain microstructure and metabolism in hepatic encephalopathy

Jessie Julie Mosso

Type C hepatic encephalopathy (HE) is a severe neuropsychiatric complication of chronic liver disease, for which the prognosis is poor in the absence of liver transplantation. Cirrhosis in type C HE leads to a toxic accumulation of ammonia in the blood, wh ...

EPFL2023

Lessons on brain edema in HE: from cellular to animal models and clinical studies

Cristina Ramona Cudalbu, Katarzyna Pierzchala, Jessie Julie Mosso

Brain edema is considered as a common feature associated with hepatic encephalopathy (HE). However, its central role as cause or consequence of HE and its implication in the development of the neurological alterations linked to HE are still under debate. I ...

SPRINGER/PLENUM PUBLISHERS2023

Diffusion-weighted MR spectroscopy: Consensus, recommendations, and resources from acquisition to modeling

Cristina Ramona Cudalbu, Jessie Julie Mosso

Brain cell structure and function reflect neurodevelopment, plasticity, and aging; and changes can help flag pathological processes such as neurodegeneration and neuroinflammation. Accurate and quantitative methods to noninvasively disentangle cellular str ...

Wiley2023

Diffusion-weighted SPECIAL improves the detection of J-coupled metabolites at ultrahigh magnetic field

Rolf Gruetter, Cristina Ramona Cudalbu, Bernard Lanz, Jessie Julie Mosso, Dunja Simicic

PurposeTo improve the detection and subsequent estimation of the diffusion properties of strongly J-coupled metabolites in diffusion-weighted MRS (DWS).MethodsA new sequence for single-voxel diffusion-weighted 1H MR spectroscopy, named DW-SPECIAL, is propo ...

WILEY2023

New Insights Into Brain Energy Metabolism in Type C Hepatic Encephalopathy: A Dual 18F-FDG PET and 9.4T 1H MRS Preclinical Study

Cristina Ramona Cudalbu, Bernard Lanz, Mario Gaetano Lepore, Jessie Julie Mosso, Carole Poitry-Yamate, Dunja Simicic, Ting Yin

Lippincott Williams & Wilkins2023

MP-PCA denoising for diffusion MRS data: promises and pitfalls

Cristina Ramona Cudalbu, Jessie Julie Mosso, Dunja Simicic

Diffusion-weighted (DW) magnetic resonance spectroscopy (MRS) suffers from a lower signal to noise ratio (SNR) compared to conventional MRS owing to the addition of diffusion attenuation. This technique can therefore strongly benefit from noise reduction s ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2022