Publications de Heyun Wang | EPFL Graph Search

Supramolecular Architectures of Dendritic Polymers Provide Irreversible Inhibitor to Block Viral Infection (Adv. Mater. 3/2025)

Francesco Stellacci, Heyun Wang, Matteo Gasbarri

Wiley2025

Facile lipid nanoparticle size engineering approach via controllable fusion induced by depletion forces

Francesco Stellacci, Milena Maria Schuhmacher, Heyun Wang

Lipid nanoparticles (LNPs) are among the most promising drug delivery carriers in research and development, with one major clinical application being messenger RNA (mRNA) vaccine. Current LNP production methods have the limit of generating low polydispersi ...

2025

Efficient Direct Cytosolic Protein Delivery via Protein-Linker Co-engineering

Francesco Stellacci, Heyun Wang, Lixia Wei, Suiyang Liao

Protein therapeutics have enormous potential for transforming the treatment of intracellular cell disorders, such as genetic disorders and cancers. Due to proteins’ cell-membrane impermeability, protein-based drugs against intracellular targets require eff ...

American Chemical Society (ACS)2025

Benzene with Alkyl Chains Is a Universal Scaffold for Multivalent Virucidal Antivirals

Francesco Stellacci, Heyun Wang, Paulo Henrique Jacob Silva, Matteo Gasbarri, Lixia Wei, Yong Zhu

Most viruses start their invasion by binding to glycoproteins' moieties on the cell surface (heparan sulfate proteoglycans [HSPG] or sialic acid [SA]). Antivirals mimicking these moieties multivalently are known as broad-spectrum multivalent entry inhibito ...

Amer Chemical Soc2024

Supramolecular Architectures of Dendritic Polymers Provide Irreversible Inhibitor to Block Viral Infection

Francesco Stellacci, Heyun Wang, Matteo Gasbarri

In Nature, most known objects can perform their functions only when in supramolecular self-assembled from, e.g. protein complexes and cell membranes. Here, a dendritic polymer is presented that inhibits severe acute respiratory syndrome coronavirus 2 (SARS ...

Wiley2024

Engineering nanomaterial surfaces for biomedical applications: antiviral surface coatings, antiviral nanoparticles and lipid-based biopharmaceutical drug systems

Heyun Wang

Nanomaterial surfaces can be engineered by chemical modifications for the modulation of various surface properties including surface charges, hydrophobicity and chemical reactivity. These properties modulate in turn the interactions between the nanomateria ...

EPFL2024

Broad-Spectrum Supramolecularly Reloadable Antimicrobial Coatings

Francesco Stellacci, Francesca Olgiati, Heyun Wang, Matteo Gasbarri, Lukasz Richter

Antimicrobial surfaces limit the spread of infectious diseases. To date, there is no antimicrobial coating that has widespread use because of short-lived and limited spectrum efficacy, poor resistance to organic material, and/or cost. Here, we present a pa ...

Amer Chemical Soc2024

Ligand concentration determines antiviral efficacy of silica multivalent nanoparticles

Francesco Stellacci, Quy Ong Khac, Xufeng Xu, Heyun Wang, Paulo Henrique Jacob Silva, Rémi Andréa La Polla

We have learned from the recent COVID-19 pandemic that the emergence of a new virus can quickly become a global health burden and kill millions of lives. Antiviral drugs are essential in our fight against viral diseases, but most of them are virus-specific ...

Academic Press Inc Elsevier Science2023

Lignin: A Sustainable Antiviral Coating Material

Harm-Anton Klok, Francesco Stellacci, Jeremy Luterbacher, Francesca Olgiati, Alice Boarino, Heyun Wang, Stefania Bertella

Transmission of viruses through contact with contaminated surfaces is an important pathway for the spread of infections. Antiviral surface coatings are useful to minimize such risks. Current state-of-the-art approaches toward antiviral surface coatings eit ...

AMER CHEMICAL SOC2022