Publications de Marianna Mainardi Koga

Strategic Insights into Engineering Parameters Affecting Cell Type-Specific Uptake of DNA-Based Nanomaterials

Maartje Martina Cornelia Bastings, Alice Comberlato, Hugo José Rodriguez Franco, Marianna Mainardi Koga

DNA-based nanomaterials are gaining popularity as uniform and programmable bioengineering tools as a result of recent solutions to their weak stability under biological conditions. The DNA nanotechnology platform uniquely allows decoupling of engineering p ...

American Chemical Society2022

Spatially Controlled Activation of Toll-like Receptor 9 with DNA-Based Nanomaterials

Maartje Martina Cornelia Bastings, Alice Comberlato, Marianna Mainardi Koga

First evidence of geometrical patterns and defined distances of biomolecules as fundamental parameters to regulate receptor binding and cell signaling have emerged recently. Here, we demonstrate the importance of controlled nanospacing of immunostimulatory ...

AMER CHEMICAL SOC2022

Selective Integrin alpha(5)beta(1) Targeting through Spatially Constrained Multivalent DNA-Based Nanoparticles

Maartje Martina Cornelia Bastings, Eva Eugene Kurisinkal, Diana Kornelia Morzy, Marianna Mainardi Koga, Vincenzo Caroprese

Targeting cells specifically based on receptor expression levels remains an area of active research to date. Selective binding of receptors cannot be achieved by increasing the individual binding strength, as this does not account for differing distributio ...

MDPI2022

IL10-and IL35-Secreting MutuDC Lines Act in Cooperation to Inhibit Memory T Cell Activation Through LAG-3 Expression

Bernard Schneider, Vanessa Laversenne, Marianna Mainardi Koga

Dendritic cells (DCs) are professional antigen-presenting cells involved in the initiation of immune responses. We generated a tolerogenic DC (tolDC) line that constitutively secretes interleukin-10 (IL10-DCs), expressed lower levels of co-stimulatory and ...

2021