Transcribing meetings with the AMIDA systems

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Deciphering the molecular events leading to the global restoration of the chromatin landscape during mitotic exit

Silja Michelle Placzek

Two fundamental properties of embryonic stem cells (ESCs) are their ability to self-renew and differentiate into all somatic cell types. Maintenance of their identity faces major challenges when transitioning through mitosis, as most DNA-binding proteins a ...

EPFL2023

Learning V1 Simple Cells with Vector Representation of Local Content and Matrix Representation of Local Motion

Yufan Ren, Siyuan Huang

This paper proposes a representational model for image pairs such as consecutive video frames that are related by local pixel displacements, in the hope that the model may shed light on motion perception in primary visual cortex (V1). The model couples the ...

ASSOC ADVANCEMENT ARTIFICIAL INTELLIGENCE2022

Algebra and geometry of link homology Lecture notes from the IHES 2021 Summer School

Oscar Salomon Kivinen

These notes cover the lectures of the first named author at 2021 IHES Summer School on "Enumerative Geometry, Physics and Representation Theory" with additional details and references. They cover the definition of Khovanov-Rozansky triply graded homology, ...

WILEY2022

A satellite DNA array barcodes chromosome 7 and regulates totipotency via ZFP819

Didier Trono, Gabriela Ecco, Helen Mary Rowe

Mammalian genomes are a battleground for genetic conflict between repetitive elements and KRAB-zinc finger proteins (KZFPs). We asked whether KZFPs can regulate cell fate by using ZFP819, which targets a satellite DNA array, ZP3AR. ZP3AR coats megabase reg ...

2022

Coxeter Combinatorics For Sum Formulas In The Representation Theory Of Algebraic Groups

Jonathan Gruber

Let G be a simple algebraic group over an algebraically closed field F of characteristic p >= h, the Coxeter number of G. We observe an easy 'recursion formula' for computing the Jantzen sum formula of a Weyl module with p-regular highest weight. We also d ...

AMER MATHEMATICAL SOC2022

From Undercomplete to Sparse Overcomplete Autoencoders to Improve LF-MMI Speech Recognition

Hervé Bourlard, Selen Hande Kabil

Starting from a strong Lattice-Free Maximum Mutual Information (LF-MMI) baseline system, we explore different autoencoder configurations to enhance Mel-Frequency Cepstral Coefficients (MFCC) features. Autoencoders are expected to generate new MFCC features ...

ISCA-INT SPEECH COMMUNICATION ASSOC2022

Epigenetic memory aids: Synaptic and molecular effects of HDAC inhibition that support memory formation

Allison Marie Burns

Learning and memory rely on synaptic communication in which intracellular signals are transported to the nucleus to stimulate transcriptional activation. Memory induced transcriptional increases are accompanied by alterations to the epigenetic landscape an ...

EPFL2022

Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections

Didier Trono, Julien Paul André Pontis, Yu Tao

The transcription factor network required for primordial germ cell (PGC) specification is known to diverge in mammals. Here the authors show that hominidae-specific transposable element (TE) LTR5Hs becomes transcriptionally active during PGC specification, ...

Nature Portfolio2022

Biochemistry of Aminoacyl tRNA Synthetase and tRNAs and Their Engineering for Cell-Free and Synthetic Cell Applications

Sebastian Maerkl, Ragunathan Bava Ganesh

Cell-free biology is increasingly utilized for engineering biological systems, incorporating novel functionality, and circumventing many of the complications associated with cells. The central dogma describes the information flow in biology consisting of t ...

FRONTIERS MEDIA SA2022

Context-dependent enhancer function revealed by targeted inter-TAD relocation

Denis Duboule, Guillaume Andrey, Lucille Delisle, Christopher Chase Bolt, Aurélie Hintermann

Here the authors show that a strong enhancer sequence can be controlled by the chromatin environment provided by a topologically associated domain (TAD) located nearby. An enhancer relocated by homologous recombination takes all the hallmarks of its new ne ...

Nature Portfolio2022

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