Publications associées à A Novel Strategy for the Design of 8-Hydroxyquinolinate- Based Lanthanide Bioprobes That Emit in the Near Infrared Range

Lanthanide Bimetallic Helicates for in Vitro Imaging and Sensing

Jean-Claude Bünzli, Anne-Sophie Chauvin, Caroline Vandevyver, Bo Song, Steve Comby

As the need for targeting luminescent biolabels increases, for mapping selected analytes, imaging of cells and organs, and tracking in cellulo processes, lanthanide bimetallic helicates are emerging as versatile bioprobes. The wrapping of three ligand stra ...

2008

Effect of the length of polyoxyethylene substituents on luminescent bimetallic lanthanide bioprobes

Jean-Claude Bünzli, Anne-Sophie Chauvin, Caroline Vandevyver, Bo Song

The new homoditopic ligand

H_2L^{C2'}

self-assembles with lanthanide ions (

Ln^{III}

) to yield neutral bimetallic helicates of overall composition

[Ln_2(L^{C2'})_3]

; it is fitted with two hexakis(oxyethylene) chains to test their effects on the thermo ...

2008

Physicochemical Properties of the High-Field MRI-Relevant [Gd(DTTA-Me)(H2O)2]− Complex

Lothar Helm, Loïck Moriggi, Cora Prestinari

To study the physicochemical properties of the DTTA chelating moiety (H4DTTA = diethylenetriaminetetraacetic acid = N,N′-[iminobis(ethane-2,1-diyl)]bis[N-(carboxymethyl)glycine]), used in several compounds proposed as magnetic resonance imaging (MRI) contr ...

2008

Towards the Rational Design of MRI Contrast Agents: Electron Spin Relaxation Is Largely Unaffected by the Coordination Geometry of Gadolinium(III)-DOTA-Type Complexes

Lothar Helm, Alain Borel, Loïck Moriggi

Electron-spin relaxation is one of the determining factors in the efficacy of MRI contrast agents. Of all the parameters involved in determining relaxivity it remains the least well understood, particularly as it relates to the structure of the complex. On ...

2008

Phosphodiester Cleavage in Ribonuclease H Occurs via an Associative Two-Metal-Aided Catalytic Mechanism

Matteo Dal Peraro

Ribonuclease H (RNase H) belongs to the nucleotidyl-transferase (NT) superfamily and hydrolyzes the phosphodiester linkages that form the backbone of the RNA strand in RNA x DNA hybrids. This enzyme is implicated in replication initiation and DNA topology ...

2008

Photoluminescent Microporous Lanthanide Silicate AV-21 Frameworks

Philip Pattison

The hydrothermal synthesis and structural characterization of the lanthanide silicate system [Na6Ln2Si12O30x H2O] (Ln=La3+, Sm3+, Eu3+, Gd3+, and Tb3+), named AV-21, has been reported. Structural elucidation of the Sm3+ analogue (isomorphous with the Eu3+, ...

2008

Non-Cytotoxic, Bifunctional EuIII and TbIII Luminescent Macrocyclic Complexes for Luminescence Resonant Energy- Transfer Experiments

Jean-Claude Bünzli, Anne-Sophie Chauvin, Caroline Vandevyver

A new macrocyclic ligand,

L^3

, has been synthesised, based on the cyclen framework grafted with three phenacyl light-harvesting groups and a C5-alkyl chain bearing a carboxylic acid function as a potential linker for biological material. Acidity constant ...

2007

Structure, dynamics and catalytic activity of ruthenium(II)-arene phosphine complexes

This thesis encompasses work on the coordination chemistry and catalytic activity of half sandwich ruthenium(II)-arene phosphine complexes. The investigation of phosphine dissociation and association reactions of these complexes represents the unifying the ...

EPFL2007

Gadolinium(III) ion in liquid water: structure, dynamics and magnetic interactions from first principles

Lothar Helm, Oleg Yazyev

We applied first principles molecular dynamics (MD) technique to study structure, dynamics, and magnetic interactions of the

Gd^{3+}

aqua ion dissolved in liquid water, a prototypical system for Gd-based complexes used as contrast agents for magnetic res ...

2007

Selective Self-Assembly of Hexameric Homo- and Heteropolymetallic Lanthanide Wheels: Synthesis, Structure, and Photophysical Studies

Jean-Claude Bünzli, Marinella Mazzanti

A rational approach to the formation of pure heteropolymetallic lanthanide complexes that uses a two-step assembly strategy and exploits the different size requirements of the two metals included in the final structure is described. The investigation of th ...

2007

A Novel Strategy for the Design of 8-Hydroxyquinolinate- Based Lanthanide Bioprobes That Emit in the Near Infrared Range

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Lanthanide Bimetallic Helicates for in Vitro Imaging and Sensing

Effect of the length of polyoxyethylene substituents on luminescent bimetallic lanthanide bioprobes

Physicochemical Properties of the High-Field MRI-Relevant [Gd(DTTA-Me)(H2O)2]− Complex

Towards the Rational Design of MRI Contrast Agents: Electron Spin Relaxation Is Largely Unaffected by the Coordination Geometry of Gadolinium(III)-DOTA-Type Complexes

Phosphodiester Cleavage in Ribonuclease H Occurs via an Associative Two-Metal-Aided Catalytic Mechanism

Photoluminescent Microporous Lanthanide Silicate AV-21 Frameworks

Non-Cytotoxic, Bifunctional EuIII and TbIII Luminescent Macrocyclic Complexes for Luminescence Resonant Energy- Transfer Experiments

Structure, dynamics and catalytic activity of ruthenium(II)-arene phosphine complexes

Gadolinium(III) ion in liquid water: structure, dynamics and magnetic interactions from first principles

Selective Self-Assembly of Hexameric Homo- and Heteropolymetallic Lanthanide Wheels: Synthesis, Structure, and Photophysical Studies

Effect of the length of polyoxyethylene substituents on luminescent bimetallic lanthanide bioprobes

Lanthanide Bimetallic Helicates for in Vitro Imaging and Sensing

Gadolinium(III) ion in liquid water: structure, dynamics and magnetic interactions from first principles

Structure, dynamics and catalytic activity of ruthenium(II)-arene phosphine complexes

Towards the Rational Design of MRI Contrast Agents: Electron Spin Relaxation Is Largely Unaffected by the Coordination Geometry of Gadolinium(III)-DOTA-Type Complexes

Phosphodiester Cleavage in Ribonuclease H Occurs via an Associative Two-Metal-Aided Catalytic Mechanism

Selective Self-Assembly of Hexameric Homo- and Heteropolymetallic Lanthanide Wheels: Synthesis, Structure, and Photophysical Studies

Physicochemical Properties of the High-Field MRI-Relevant [Gd(DTTA-Me)(H2O)2]− Complex

Photoluminescent Microporous Lanthanide Silicate AV-21 Frameworks

Non-Cytotoxic, Bifunctional EuIII and TbIII Luminescent Macrocyclic Complexes for Luminescence Resonant Energy- Transfer Experiments