Nestin-Cre transgenic mouse line Nes-Cre1 mediates highly efficient Cre/loxP mediated recombination in the nervous system, kidney and somite-derived tissues
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The large-scale structure of complex systems is intimately related to their functionality and evolution. In particular, global transport processes in flow networks rely on the presence of directed pathways from input to output nodes and edges, which organi ...
Definition of single spikes from multiunit spike trains plays a critical role in neurophysiology and in neuroengineering. Moreover, long period analysis are needed to study synaptic plasticity effects and observe the long and medium term development on whi ...
BACKGROUND: Gene transfer to nociceptive neurons of the dorsal root ganglia (DRG) is a promising approach to dissect mechanisms of pain in rodents and is a potential therapeutic strategy for the treatment of persistent pain disorders such as neuropathic pa ...
A major challenge to understanding behavior is how the nervous system allows the learning of behavioral sequences that can occur over arbitrary timescales, ranging from milliseconds up to seconds, using a fixed millisecond learning rule. This article descr ...
The epigenetic marking of chromatin provides a ubiquitous means for cells to shape and maintain their identity, and to react to environmental stimuli via specific remodeling. Such an epigenetic code of the core components of chromatin, DNA and histone prot ...
Although straight point to point movements have been successfully modeled until now, many reaching movements are not straight neither in hand Cartesian nor in joint angles space, such as for example movements directed towards oneself. Addressing the genera ...
Neurodegenerative diseases are more and more prevalent in our aging societies. A rapid overview of the etiology of many neurodegenerative diseases like Alzheimer, Parkinson, Huntington disease and amyotrophic lateral sclerosis suggests a tight link with mi ...
The apolipoprotein E (apoE) genotype is an important genetic risk factor for Alzheimer's disease (AD). In the central nervous system (CNS), most apoE is produced by astrocytes and is present in unique high-density lipoprotein (HDL)-like particles that have ...
The hypothalamus plays an essential role in the central nervous system of mammals by among others regulating glucose homeostasis, food intake, temperature, and to some extent blood pressure. Assessments of hypothalamic metabolism using, e.g. 1H MRS in mous ...
Reach-to-grasp tasks are composed of several actions that are more and more considered as simultaneously controlled by the central nervous system in a feedforward manner (at least for well-known activities). If this hypothesis is correct, during prehension ...
