Telomerase unplugged

Joachim Lingner, Katarzyna Sikora
2007
Article

Résumé

The control of telomerase activity at chromosome ends by telomere-binding proteins is critical for telomere length homeostasis. Two recent papers identify TPP1 as a critical mediator of this control. TPP1 forms part of the telomeric shelterin complex while also associating with telomerase, stimulating its activity and processivity.

Source officielle

https://infoscience.epfl.ch/record/114207?ln=fr

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Telomerase unplugged

The THO complex counteracts TERRA R-loop-mediated telomere fragility in telomerase(+) cells and telomeric recombination in ALT(+) cells

The makings of TERRA R-loops at chromosome ends

RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops

The makings of TERRA R-loops at chromosome ends

The THO complex counteracts TERRA R-loop-mediated telomere fragility in telomerase(+) cells and telomeric recombination in ALT(+) cells

RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops