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The KRAB repressor domain can trigger de novo promoter methylation during mouse early embryogenesis

Publications associées (55)

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Essential Nucleoid Associated Protein mIHF (Rv1388) Controls Virulence and Housekeeping Genes in Mycobacterium tuberculosis

Stewart Cole, Nina Theres Odermatt, Claudia Sala, Andrej Benjak

Tight control of gene expression is crucial for Mycobacterium tuberculosis to adapt to the changing environments encountered when infecting or exiting human cells. While three nucleoid associated proteins (NAPs) EspR, HupB and Lsr2 have been investigated, ...

NATURE PUBLISHING GROUP2018

Rhythmic and clock-dependent chromatin loops regulate circadian gene expression

Jérôme Mermet

In mammals the circadian clock drives daily behavioural and physiological changes that resonate with environmental cues, which can be observed, for example, in the intricate timing of rest during the night and activity during the day in humans. The circadi ...

EPFL2017

KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks

Didier Trono, Michaël Imbeault, Pierre-Yves Joseph Laurent Helleboid

The human genome encodes some 350 Kruppel-associated box (KRAB) domain-containing zinc-finger proteins (KZFPs), the products of a rapidly evolving gene family that has been traced back to early tetrapods(1,2). The function of most KZFPs is unknown, but a f ...

Nature Publishing Group2017

Gene regulatory mechanisms underlying the intestinal innate immune response

Bart Deplancke, Antonio Carlos Alves Meireles Filho

In the mammalian gastrointestinal tract, distinct types of cells, including epithelial cells and macrophages, collaborate to eliminate ingested pathogens while striving to preserve the commensal microbiota. The underlying innate immune response is driven b ...

Elsevier2017

Bicistronic aav vector for rna interference in als

Bernard Schneider, Cylia Cloé Rochat

The present invention relates to a bicistronic expression vector for silencing a gene specifically in astrocytes and neurons, comprising two expression cassettes comprising a first and a second silencer sequence, respectively, wherein the expression of sai ...

2017

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Methylated arsenic (As) species represent a significant fraction of the As accumulating in rice grains, and there are geographic patterns in the abundance of methylated arsenic in rice that are not understood. The microorganisms driving As biomethylation i ...

Amer Chemical Soc2017

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Deposition of epigenetic marks is an important layer of the transcriptional control of retrotransposons, especially during early embryogenesis. Krüppel-associated box domain zinc finger proteins (KRAB-ZFPs) are one of the largest families of transcription ...

2016

TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells

Didier Trono, Priscilla Turelli, Adamantia Kapopoulou, Johan Jakobsson

TRIM28 is a corepressor that mediates transcriptional silencing by establishing local heterochromatin. Here, we show that deletion of TRIM28 in neural progenitor cells (NPCs) results in high-level expression of two groups of endogenous retroviruses (ERVs): ...

Elsevier2015

The Developmental Control of Transposable Elements and the Evolution of Higher Species

Didier Trono, Marc Samuel Friedli

Transposable elements (TEs) account for at least 50% of the human genome. They constitute essential motors of evolution through their ability to modify genomic architecture, mutate genes and regulate gene expression. Accordingly, TEs are subject to tight e ...

Annual Reviews2015

KAP1 is a universal corepressor for the large family of KRAB-ZFP proteins that coordinates epigenetic silencing of endogenous retroelements (EREs) during early embryonic development. This process is essential not just to prevent replication of EREs, but al ...

EPFL2015