Publication

Functional analysis of T lymphocyte subsets in antiviral host defense

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The advent of immunotherapy, such as immune checkpoint blockade (ICB) and adoptive transfer of cytotoxic lymphocytes, has transformed the clinical care of cancer. However, a significant proportion of patients are resistant to immunotherapy or experience re ...

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BackgroundDepression and anxiety are known to be associated with stress-induced changes in the immune system. Bothersome tinnitus can be related to stress and often co-occurs with depression and anxiety. This study investigates associations of psychologica ...

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Variability of Primary Sjogren's Syndrome Is Driven by Interferon alpha and Interferon alpha Blood Levels Are Associated With the Class II HLA-DQ Locus

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Type I Interferon Signaling Prevents IL-1 beta-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue

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Type I interferons (IFN-Is) are fundamental for antiviral immunity, but their role in bacterial infections is contradictory and incompletely described. Streptococcus pyogenes activates IFN-I production in innate immune cells, and IFN-I receptor 1 (Ifnar1)- ...

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NK Cells Respond to Haptens by the Activation of Calcium Permeable Plasma Membrane Channels

Horst Vogel, Horst Pick

Natural Killer (NK) cells mediate innate immunity to infected and transformed cells. Yet, NK cells can also mount hapten-specific recall responses thereby contributing to contact hypersensitivity (CHS). However, since NK cells lack antigen receptors that a ...

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Conditional Deletion of Ferritin H in Mice Reduces B and T Lymphocyte Populations

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The immune system and iron availability are intimately linked as appropriate iron supply is needed for cell proliferation, while excess iron, as observed in hemochromatosis, may reduce subsets of lymphocytes. We have tested the effects of a ferritin H gene ...

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TLR4- and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T cell-independent isotype switch in mice

Pedro Miguel Nunes Pereira de Almeida Reis, Andrea Pfeifer, Marija Vukicevic, Andreas Muhs, Valérie Gafner, Anna Lucia Buccarello

Immunoglobulin class switching from IgM to IgG in response to peptides is generally T cell-dependent and vaccination in T cell-deficient individuals is inefficient. We show that a vaccine consisting of a dense array of peptides on liposomes induced peptide ...

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Species-specific detection of the antiviral small-molecule compound CMA by STING

Andrea Ablasser

Extensive research on antiviral small molecules starting in the early 1970s has led to the identification of 10-carboxymethyl-9-acridanone (CMA) as a potent type I interferon (IFN) inducer. Up to date, the mode of action of this antiviral molecule has rema ...

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