Correlating whisker behavior with membrane potential in barrel cortex of awake mice
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Changes of synaptic connections between neurons are thought to be the physiological basis of learning. These changes can be gated by neuromodulators that encode the presence of reward. We study a family of reward-modulated synaptic learning rules for spiki ...
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We introduce a preconditioner for the solution of the Bidomain system governing the propagation of action potentials in the myocardial tissue. The Bidomain model is a degenerate parabolic set of nonlinear reaction-diffusion equations. The nonlinear term de ...
By placing axons into polymeric microchannels hosting embedded electrodes the extracellular amplitude of action potentials is greatly increased, allowing for robust recording and noise suppression. We are developing such an electrode interface to record el ...
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Internal brain states form key determinants for sensory perception, sensorimotor coordination and learning. A prominent reflection of different brain states in the mammalian central nervous system is the presence of distinct patterns of cortical synchrony, ...
One important challenge of microsystems design is the implementation of miniaturized actuation principles efficient at the micro-scale. Shape memory alloys (SMAs) have early on been considered as a potential solution to this problem as these materials offe ...
One important challenge of microsystems design is the implementation of miniaturized actuation principles efficient at the micro-scale. Shape memory alloys (SMAs) have early on been considered as a potential solution to this problem as these materials offe ...
Cortical dynamics can be imaged at high spatiotemporal resolution with voltage-sensitive dyes (VSDs) and calcium-sensitive dyes (CaSDs). We combined these two imaging techniques using epifluorescence optics together with whole cell recordings to measure th ...
Nicotinic acetylcholine receptors are heteropentameric ion channels that open upon activation to a single conducting state. The second transmembrane segments of each subunit were identified as channel-forming elements, but their respective contribution in ...
Neurons in the central nervous system, and in the cortex in particular, are subject to a barrage of pulses from their presynaptic populations. These synaptic pulses are mediated by conductance changes and therefore lead to increases or decreases of the neu ...
