Publication
Role of secretory component, a secreted glycoprotein, in the specific uptake of IgA dimer by epithelial cells
Publications associées (38)
Selective integrin targeting with DNA-based nanomaterials
Targeting cells specific to type and state remains a challenge in developing effective therapies, sensitive diagnostics, also robust and versatile tissue engineering. A promising strategy is to focuses on improving the inherent selectivity of the targeting ...
EPFL202290 YEARS OF PROGESTERONE Progesterone receptor signaling in the normal breast and its implications for cancer
Cathrin Brisken, Valentina Scabia
Progesterone is considered as the pregnancy hormone and acts on many different target tissues. Progesterone receptor (PR) signaling is important for normal development and the physiologic function of the breast and impinges on breast carcinogenesis. Both s ...
BIOSCIENTIFICA LTD2020The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche
Cathrin Brisken, Giovanna Ambrosini, Marian Caikovski, Philipp Bucher, Renuga Devi Rajaram, Patrik Aouad, Dalya Ataca, Marie Shamseddin, Céline Berthe Constantin, Csaba Ferenc László
Estrogens and progesterone control breast development and carcinogenesis via their cognate receptors expressed in a subset of luminal cells in the mammary epithelium. How they control the extracellular matrix, important to breast physiology and tumorigenes ...
2020Membrane expression of the estrogen receptor ER alpha is required for intercellular communications in the mammary epithelium
Cathrin Brisken, Stéphanie Cagnet
17 beta-Estradiol induces the postnatal development of mammary gland and influences breast carcinogenesis by binding to the estrogen receptor ER alpha. ER alpha acts as a transcription factor but also elicits rapid signaling through a fraction of ER alpha ...
COMPANY BIOLOGISTS LTD2020Targeted protein degradation through cytosolic delivery of monobody binders using bacterial toxins
Oliver Hantschel, Nadine Eliane Schmit, Katyayanee Neopane
Monobodies are small engineered binding proteins that, upon expression in cells, can inhibit signaling of cytosolic oncoproteins with outstanding selectivity. Efficacy may be further increased by inducing degradation of monobody targets through fusion to t ...
2019Adamts18 Function in Mammary Gland Development
Ovarian hormones control mammary gland development and impinge on breast carcinogenesis acting via their cognate receptors in the luminal epithelium. The extracellular matrix has a key role in physiology and disease but how the two are linked is poorly und ...
EPFL2019Oestrogen receptor alpha AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium
Cathrin Brisken, Georgios Sflomos, Ayyakkannu Ayyanan, Valentina Scabia, Patrik Aouad, Dalya Ataca, Stéphanie Cagnet
Oestrogen receptor alpha (ER alpha) is a transcription factor with ligand-independent and ligand-dependent activation functions (AF)-1 and -2. Oestrogens control postnatal mammary gland development acting on a subset of mammary epithelial cells (MECs), ter ...
NATURE PUBLISHING GROUP2018Cytosolic delivery and characterization of monobodies interfering with SH2 domain-phosphotyrosine interactions
Targeted cancer therapy is a very promising concept; however, small molecule inhibitors only exist for a limited number of oncoproteins and resistance development limits their clinical use. Different engineered non-antibody scaffolds are being explored to ...
EPFL2018In vivo reprogramming of non-mammary cells to an epithelial cell fate is independent of amphiregulin signaling
Cathrin Brisken, Stéphanie Cagnet
AREG-/- mice demonstrate impaired mammary development and form only rudimentary ductal epithelial trees, however, AREG-/- glands are still capable of undergoing alveologenesis and lactogenesis during pregnancy. Transplantation of AREG-/- mammary epithelial ...
Company of Biologists2017The Principles of Ligand Specificity on beta-2-adrenergic receptor
G protein-coupled receptors are recognized as one of the largest families of membrane proteins. Despite sharing a characteristic seven-transmembrane topology, G protein-coupled receptors regulate a wide range of cellular signaling pathways in response to v ...
Nature Publishing Group2016