Endocytosis of the transferrin receptor requires the cytoplasmic domain but not its phosphorylation site
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Parkinson's disease (PD) is a neurologic disorder resulting from the loss of dopaminergic neurons in the brain. Two lines of evidence suggest that the protein alpha-synuclein plays a role in the pathogenesis of PD: Fibrillar alpha-synuclein is a major comp ...
Reversible protein phosphorylation is a major regulation mechanism of fundamental biological processes, not only in eukaryotes but also in bacteria. A growing body of evidence suggests that Ser/Thr phosphorylation play important roles in the physiology and ...
A review. Directed evolution consists of repetitive cycles of random mutagenesis of the protein/peptide sequence followed by screening or selection of candidates with desired properties. Many different approaches are used to introduce mutations into a gene ...
In this issue of Cell, Coppens and coworkers (Coppens et al., 2006) describe how Toxoplasma gondii, an obligate intracellular parasite, feeds on the host. Coppens et al. provide evidence that the parasite takes host cell endosomes and lysosomes hostage by ...
Morphogenetic pathways govern the processes that underlie embryonic development as well as self-renewal and homeostasis in adult tissues. The Genetics Company (TGC) exploits the untapped potential of morphogenetic pathways to develop new therapeutic approa ...
We describe a new procedure to identify RNA or DNA binding sites in proteins, based on a combination of UV cross-linking and single-hit chemical peptide cleavage. Site-directed mutagenesis is used to create a series of mutants with single Asn-Gly sequences ...
A novel isomer of C70(CF3)6 has been isolated by HPLC from a mixture prepared by trifluoromethylation of C70 with CF3COOAg. The X-ray structure revealed an unprecedented arrangement of CF3 groups forming a p3mp ribbon. This result provides additional evide ...
An extensive random mutagenesis study on the function of nine residues in the subunit binding site of FimC was conducted to evaluate the mol. mechanisms of subunit binding by FimC and the contribution of chaperone surface residues. Five plasmid libraries o ...
Deutsche Akademie der Naturforscher Leopoldina2001
TaSe3 belongs to a class of low-dimensional materials characterized by the interplay and competition between dimensionality crossover and broken symmetry ground states. A comprehensive study by dc-transport, optical, and angle-resolved photoemission (ARPES ...
Vasomotion has been studied on segments of rat mesenteric and femoral arteries perfused in vitro. We have investigated 1) the effect of perfusion flow on the characteristics of vasomotion and 2) the nature and patterns of vasomotion. We have found that per ...
