Publication

Synaptic dynamics control the timing of neuronal excitation in the activated neocortical microcircuit

Publications associées (34)

Network Activity and Plasticity

The cortex must maintain balanced levels of neural activity to correctly integrate inputs and to provide contextually meaningful outputs. Neuronal excitation is counterbalanced by various forms of inhibition such as spike frequency adaptation, short- and l ...

EPFL2013

Matched Pre- and Post-Synaptic Changes Underlie Synaptic Plasticity over Long Time Scales

Henry Markram, Jean-Vincent Le Bé

Modifications of synaptic efficacies are considered essential for learning and memory. However, it is not known how the underlying functional components of synaptic transmission change over long time scales. To address this question, we studied cortical sy ...

Soc Neuroscience2013

Microcircuits of excitatory and inhibitory neurons in layer 2/3 of mouse barrel cortex

Wulfram Gerstner, Carl Petersen, Céline Matéo, Michael Avermann, Christian Tomm

Avermann M, Tomm C, Mateo C, Gerstner W, Petersen CC. Microcircuits of excitatory and inhibitory neurons in layer 2/3 of mouse barrel cortex. J Neurophysiol 107: 3116-3134, 2012. First published March 7, 2012; doi:10.1152/jn.00917.2011.-Synaptic interactio ...

American Physiological Society2012

Long-Term Depression at Parallel Fiber to Golgi Cell Synapses

Michele Giugliano

Robberechts Q, Wijnants M, Giugliano M, De Schutter E. Longterm depression at parallel fiber to Golgi cell synapses. J Neurophysiol 104: 3413-3423, 2010. First published September 22, 2010; doi:10.1152/jn.00030.2010. Golgi cells (GoCs) are the primary inhi ...

2010

Spike-timing dependent plasticity

Wulfram Gerstner

Spike Timing Dependent Plasticity (STDP) is a temporally asymmetric form of Hebbian learning induced by tight temporal correlations between the spikes of pre- and postsynaptic neurons. As with other forms of synaptic plasticity, it is widely believed that ...

2010

Structure and function of the olfactory bulb microcircuit

Michele Pignatelli

The aim of this study is to contribute to understand the physiology of the Olfactory System through detailed microcircuit investigation, adopting advanced electrophysiological and anatomical techniques. Multiple patch clamp recordings allow understanding t ...

EPFL2009

The Excitatory Neuronal Network of the C2 Barrel Column in Mouse Primary Somatosensory Cortex

Carl Petersen, Juan-Carlos Sarria, Sandrine Lefort, Christian Tomm

Local microcircuits within neocortical columns form key determinants of sensory processing. Here, we investigate the excitatory synaptic neuronal network of an anatomically defined cortical column, the C2 barrel column of mouse primary somatosensory cortex ...

2009

Spike-Based Reinforcement Learning in Continuous State and Action Space: When Policy Gradient Methods Fail

Wulfram Gerstner, Eleni Vasilaki, Nicolas Frémaux, Walter Senn

Changes of synaptic connections between neurons are thought to be the physiological basis of learning. These changes can be gated by neuromodulators that encode the presence of reward. We study a family of reward-modulated synaptic learning rules for spiki ...

Public Library of Science2009

Synaptic plasticity across different time scales and its functional implications

Claudia Clopath

Humans and animals learn by modifying the synaptic strength between neurons, a phenomenon known as synaptic plasticity. These changes can be induced by rather short stimuli (lasting, for instance, only a few seconds), yet, in order to be useful for long-te ...

EPFL2009

Developmental regulation of the intracellular Ca2+ sensitivity of vesicle fusion and Ca2+-secretion coupling at the rat calyx of Held

Ralf Schneggenburger, Olexiy Kochubey, Yunyun Han

Developmental refinement of synaptic transmission can occur via changes in several pre- and postsynaptic factors, but it has been unknown whether the intrinsic Ca2+ sensitivity of vesicle fusion in the nerve terminal can be regulated during development. Us ...

2009

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