Publication
The Notch pathway: hair graying and pigment cell homeostasis
Publications associées (78)
A locally activatable sensor for robust quantification of organellar glutathione
Pablo Rivera Fuentes, Sarah Emmert, Gianluca Quargnali
Glutathione (GSH) is the main determinant of intracellular redox potential and participates in multiple cellular signalling pathways. Achieving a detailed understanding of intracellular GSH homeostasis depends on the development of tools to map GSH compart ...
NATURE PORTFOLIO2023Notch1 signaling is limited in healthy mature kidneys in vivo
ObjectiveA Delta-Notch signaling component, Notch1, is involved in the normal development and multiple disorders of the kidney. Although the increase in Notch1 signaling is crucial to these pathogeneses, the basal signaling level in 'healthy' mature kidney ...
SPRINGERNATURE2023Mind blanking is a distinct mental state linked to a recurrent brain profile of globally positive connectivity during ongoing mentation
Dimitri Nestor Alice Van De Ville, Sepehr Mortaheb
Mind blanking (MB) is a waking state during which we do not report any mental con-tent. The phenomenology of MB challenges the view of a constantly thinking mind. Here, we comprehensively characterize the MB's neurobehavioral profile with the aim to deline ...
NATL ACAD SCIENCES2022Towards engineering an artificial neural tube
In this thesis, I present a self-organizing neural tube organoid that is strikingly similar in morphology, cell-type composition, and patterning to the mouse embryonic neural tube. When exposed to a sequence of epiblast culture conditions and neural differ ...
EPFL2021REX technologies for profiling and decoding the electrophile signaling axes mediated by Rosetta Stone proteins
It is now clear that some cysteines on some proteins are highly tuned to react with electrophiles. Based on numerous studies, it is also established that electrophile sensing underpins rewiring of several critical signaling processes. These electrophile-se ...
ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD2020What are you synching about? Emerging complexity of Notch signaling in the segmentation clock
Andrew Charles Oates, Olivier François Venzin
The Segmentation clock is a population of cellular genetic oscillators, located in the posterior of the elongating vertebrate embryo, that governs the rhythmic and sequential segmentation of the body axis into somites. Somites are blocks of cells that give ...
ACADEMIC PRESS INC ELSEVIER SCIENCE2020Triggering of a Dll4–Notch1 loop impairs wound healing in diabetes
Diabetic foot ulcerations (DFUs) represent a major medical, social, and economic problem. Therapeutic options are restricted due to a poor understanding of the pathogenic mechanisms. The Notch pathway plays a pivotal role in cell differentiation, prolifera ...
2019Closed-loop Controlled Brillouin Optical Time-domain Analysis
A novel concept to retrieve information in Brillouin distributed fiber sensors is presented, in which the interacting signals are conditioned to track a uniform gain along the fiber, showing 100× faster acquisition at similar accuracy. ...
Optical Society of America2018Glycosphingolipid metabolic reprogramming drives neural differentiation
Giovanni D'Angelo, Riccardo Rizzo
Neural development is accomplished by differentiation events leading to metabolic reprogramming. Glycosphingolipid metabolism is reprogrammed during neural development with a switch from globo- to ganglio-series glycosphingolipid production. Failure to exe ...
2018Notch as a tumour suppressor
The Notch signalling cascade is an evolutionarily conserved pathway that has a crucial role in regulating development and homeostasis in various tissues. The cellular processes and events that it controls are diverse, and continued investigation over recen ...
Nature Publishing Group2017