Publication
Atrial Repolarization Alternans in a Chronic Sheep Model of Pacing-Induced Atrial Fibrillation
Publications associées (123)
An integrated heart-torso electromechanical model for the simulation of electrophysiological outputs accounting for myocardial deformation
Alfio Quarteroni, Francesco Regazzoni
When generating in-silico clinical electrophysiological outputs, such as electrocardiograms (ECGs) and body surface potential maps (BSPMs), mathematical models have relied on single physics, i.e. of the cardiac electrophysiology (EP), neglecting the role o ...
Elsevier Science Sa2024Finding information-rich electrocardiographic biomarkers to characterize atrial fibrillation.
Atrial fibrillation (AF) is the most common cardiac arrhythmia; it will affect one in four adults worldwide in their lifetime. AF has serious consequences, including drastically increased risk of stroke. Catheter ablation surgery is an established treatmen ...
EPFL2023Active force generation contributes to the complexity of spontaneous activity and to the response to stretch of murine cardiomyocyte cultures
Cardiomyocyte cultures exhibit spontaneous electrical and contractile activity, as in a natural cardiac pacemaker. In such preparations, beat rate variability exhibits features similar to those of heart rate variability in vivo. Mechanical deformations and ...
WILEY2022Correlation between conduction velocity and frequency analysis in patients with atrial fibrillation using high-density charge mapping
Spectral analysis of atrial signals has been used to identify regions of interest in atrial fibrillation (AF). However, the relationship to the atrial substrate is unclear. In this study, we compare regions with dominant frequency (DF), simultaneously dete ...
SPRINGER HEIDELBERG2022Novel spatiotemporal processing tools for body-surface potential map signals for the prediction of catheter ablation outcome in persistent atrial fibrillation
Jean-Marc Vesin, Adrian Luca, Etienne Pruvot
Background: Signal processing tools are required to efficiently analyze data collected in body-surface-potential map (BSPM) recordings. A limited number of such tools exist for studying persistent atrial fibrillation (persAF). We propose two novel, spatiot ...
FRONTIERS MEDIA SA2022Evaluation and optimization of novel extraction algorithms for the automatic detection of atrial activations recorded within the pulmonary veins during atrial fibrillation
Jean-Marc Vesin, Adrian Luca, Yann Prudat, Sasan Yazdani, Etienne Pruvot
Background and objective The automated detection of atrial activations (AAs) recorded from intracardiac electrograms (IEGMs) during atrial fibrillation (AF) is challenging considering their various amplitudes, morphologies and cycle length. Activation time ...
BMC2022Mitochondrial Creatine Kinase Attenuates Pathologic Remodeling in Heart Failure
Yi Zhang, Annina Stuber, Ashish Gupta
BACKGROUND: Abnormalities in cardiac energy metabolism occur in heart failure (HF) and contribute to contractile dysfunction, but their role, if any, in HF-related pathologic remodeling is much less established. CK (creatine kinase), the primary muscle ene ...
LIPPINCOTT WILLIAMS & WILKINS2022A Computational Study of the Electrophysiological Substrate in Patients Suffering From Atrial Fibrillation
Alfio Quarteroni, Andrea Manzoni
In the context of cardiac electrophysiology, we propose a novel computational approach to highlight and explain the long-debated mechanisms behind atrial fibrillation (AF) and to reliably numerically predict its induction and sustainment. A key role is pla ...
FRONTIERS MEDIA SA2021Association of Heart Rate Variability With Silent Brain Infarcts in Patients With Atrial Fibrillation
Jean-Marc Vesin, Vincent Schlageter
Purpose: Silent brain infarcts (SBI) are frequently detected in patients with atrial fibrillation (AF), but it is unknown whether SBI are linked to autonomic dysfunction. We aimed to explore the association of autonomic dysfunction with SBI in AF patients. ...
FRONTIERS MEDIA SA2021ECG-Based Indices to Characterize Persistent Atrial Fibrillation Before and During Stepwise Catheter Ablation
Jean-Marc Vesin, Adrian Luca, Etienne Pruvot
Background: Consistently successful patient outcomes following catheter ablation (CA) for treatment of persistent atrial fibrillation (pers-AF) remain elusive. We propose an electrocardiogram (ECG) analysis designed to (1) refine selection of patients most ...
FRONTIERS MEDIA SA2021