Publication

Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis

Publications associées (32)

Activation and Spatial Organization of the Adenosine A2A Receptor in Supported Plasma Membrane Sheets

G protein-coupled receptors (GPCRs) are ubiquitous mediators of signal transduction across cell membranes and constitute a very important class of therapeutic targets. The main mechanisms involving GPCR activation and signal transduction to the cell interi ...

EPFL2013

Connecting vesicular transport with lipid synthesis: FAPP2

Giovanni D'Angelo

Next to the protein-based machineries composed of small G-proteins, coat complexes, SNAREs and tethering factors, the lipid-based machineries are emerging as important players in membrane trafficking. As a component of these machineries, lipid transfer pro ...

2012

Transmembrane Signaling Analysis in Model Membrane Systems

Luigino Grasso

Studying the complex mechanisms of transducing an extracellular signal across a plasma membrane to initiate an intracellular responce is of fundamental importance for a cell’s function. Transmembrane signaling is the key allowing cells to sense and communi ...

EPFL2012

Cell-type-specific 2 adrenergic receptor clusters identified using photo-activated localization microscopy are not lipid raft related, but depend on actin cytoskeleton integrity

Aleksandra Radenovic, Paolo Annibale, Marco Scarselli

Recent developments in the field of optical super-resolution techniques allow both a 10-fold increase in resolution as well as an increased ability to quantify the number of labeled molecules visualized in the fluorescence measurement. By using photoactiva ...

2012

Translocation of HIV TAT peptide and analogues induced by multiplexed membrane and cytoskeletal interactions

Li Tang, Amaresh Mishra

Cell-penetrating peptides (CPPs), such as the HIV TAT peptide, are able to translocate across cellular membranes efficiently. A number of mechanisms, from direct entry to various endocytotic mechanisms (both receptor independent and receptor dependent), ha ...

2011

Anthrax toxin triggers the activation of src-like kinases to mediate its own uptake

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Béatrice Kunz

AB-type toxins, like other bacterial toxins, are notably opportunistic molecules. They rely on target cell receptors to reach the appropriate location within the target cell where translocation of their enzymatic subunits occurs. The anthrax toxin, however ...

National Academy of Sciences2010

Imaging of G protein-coupled receptors in solid-supported planar lipid membranes

Theo Lasser, Marcel Leutenegger

This contribution summarizes first some of our efforts in imaging G-protein-coupled receptor (GPCR) functional inserted into planar tethered lipid bilayer membranes (tBLMs) as a novel platform for biophysical studies. The authors introduced recently a nove ...

2009

Imaging of G protein-coupled receptors in solid-supported planar membranes at the single molecule level

Theo Lasser, Marcel Leutenegger

Odorant receptors are an excellent example of natural superiority in binding specific, small and hydrophobic molecules, and therefore are of particular interest in the development of a sensor platform for G protein-coupled receptors (GPCRs). Odorant recept ...

2008

Imaging of G protein-coupled receptors in solid- supported planar membranes at the single molecule level

Theo Lasser, Marcel Leutenegger

Odorant receptors are an excellent example of natural superiority in specifically binding specific, small and hydrophobic molecules. They are of particular interest in the development of a sensor platform for G protein- coupled receptors (GPCRs). Odorant r ...

SPIE2008

Miniaturized bioanalytics to probe the function of membrane proteins

Pedro Pascoal

G-protein coupled receptors (GPCRs) are the most abundant class of proteins in the cell body. Such receptors are of major interest as potential therapeutic targets. Downscaling and parallelization of bioanalytics opens novel routes to rapidly screen and id ...

EPFL2008

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