Biocompatibility of Si-based arrays of electrodes coupled to organotypic hippocampal brain slice cultures
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Robberechts Q, Wijnants M, Giugliano M, De Schutter E. Longterm depression at parallel fiber to Golgi cell synapses. J Neurophysiol 104: 3413-3423, 2010. First published September 22, 2010; doi:10.1152/jn.00030.2010. Golgi cells (GoCs) are the primary inhi ...
Interfacing organic electronics and biology offers new possibilities in biotechnology, due to the unique properties exhibited by organic conducting polymers (e.g. biological affinity, mechanical flexibility, ease of functionalization and cost effectiveness ...
The ability of culturing neurons for a long time on MicroElectrode Array (MEA) devices plays a critical role in understanding some long-term behaviors of a neuronal network, such as the long-term synaptic plasticity. Moreover, pharmacological outcomes usua ...
The neocortex is the most computationally advanced portion of the brain. It is currently assumed to be composed of a large number of "cortical columns" – intricate arrangements of cortical neurons approximately 300-500 µm in diameter and 2-5 mm in height i ...
The design of novel bidirectional interfaces for in vivo and in vitro nervous systems is an important step towards future functional neuroprosthetics. Small electrodes, structures and devices are necessary to achieve high-resolution and target-selectivity ...
The design of novel bidirectional interfaces for in vivo and in vitro nervous systems is an important step towards future functional neuroprosthetics. Small electrodes, structures and devices are necessary to achieve high-resolution and target-selectivity ...
The present invention concerns a new pharmaceutical composition comprising an antagonist and a co-agonist of the N-methyl-D-aspartate-type glutamate receptor (NMDAR). The inventors found that the co-administration of these two compounds effectively inhibit ...
This work presents implantable, flexible polymer-based probes with embedded microelectrodes for acute and chronic neural recordings in vivo, as tested on rodents. Acute recordings using this array were done in mice under urethane anesthesia and compared to ...
Abstract—Mapping neuronal networks activity of in-vitro cell cultures with microelectrode array (MEA) based systems, providing a spatial resolution down to cellular/sub-cellular levels and an adequate temporal resolution for resolving action potential prop ...
The interest in new materials and their application in the neuroscience are growing incredibly fast. Current research interests are increasingly focusing on new artificial materials and their direct effects on the central nervous systems so that it would b ...