Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils
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In the present work, CeO2 nanopowder was synthesized via a reverse precipitation method using CeCl3 center dot 7H(2)O, NH4OH and sodium dodecyl sulfate as raw materials. The effect of thermal treatment on the crystal growth, surface area and chemical bonds ...
Surface processing of a Ti–6Al–4V alloy led to a complex multilayered microstructure containing several phases of the Ni–Ti–P–Al–O system, which improves the mechanical and tribological surface properties. The microstructure, chemical and phase composition ...
Nanostructure ZnO hollow microspheres with average crystallite size of about 15 nm, and average diameters of about 1 mu m, were successfully fabricated through a novel hydrothermal method. Hollow microspheres were formed due to self-assembly of ZnO oblong ...
Electron crystallography of membrane proteins determines the structure of membrane-reconstituted and two-dimensionally (2D) crystallized membrane proteins by low-dose imaging with the transmission electron microscope, and computer image processing. We have ...
To investigate structure and function of different monoclonal antibody (MAb) dimers.MAb dimers were induced by process-related, low pH and UV light stress. Dimers were isolated and purified by chromatography and extensively characterized by biochemical, st ...
A comparative characterization of the structure of normal and abnormal (osteoporotic) human lumbar and thoracic vertebrae samples was carried out to reveal the type of possible disorder. Samples from the bone fragments extracted during the surgery due to v ...
α-Synuclein aggregates in Lewy bodies and plays a central role in the pathogenesis of a group of neurodegenerative disorders, known as "Synucleinopathies", including Parkinson's disease. Parkin mutations result in loss of parkin E3-ubiquitin ligase activit ...
The aim of this work was to develop a controllable route to produce a stable and inorganic layer on the surface of multi-wall carbon nanotubes. Precursor compounds such as TiBr4, TiCl4, Ti(OiPr)(4), and Ti(OEt)(4) were used to cover the surface of carbon n ...
The third and most recently identified Parkinson's disease-linked variant of the neuronal protein alpha-synuclein to be identified (E46K) results in widespread brain pathology and early onset Parkinson symptoms (Zarranz et al. (2004) Ann. Neurol. 55, 164-1 ...
