Aquaporins in brain: distribution, physiology, and pathophysiology
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The brain of a hibernating mammal withstands physiological extremes that would result in cerebral damage and death in a non-hibernating species such as humans. To examine the possibility that this neuroprotection results from alterations in cerebral metabo ...
Arterial spin labeling (ASL) uses proximally inverted blood water spins as an endogenous contrast agent to measure blood perfusion in tissue. In this work pulsed ASL was used to measure the kinetic curves of cerebral blood flow (CBF) across eight anatomica ...
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the elderly population. AD currently affects approximately 27 million people worldwide. A pathological hallmark of AD is the accumulation and deposition of the amyloid beta (Aβ) pe ...
This thesis work aims to optimize the treatment of hydrocephalus. It consists of two distinct objectives: the optimization of the diagnosis of patients implanted with a shunt system for the derivation of cerebro-spinal fluid (CSF) and the optimization of t ...
Cerebral vasospasm is a typical complication occurring after Subarachnoid Hemorrhage, which may
lead to delayed cerebral ischemia and death. The standard method to detect vasospasm is
angiography, which is an invasive procedure. Monitoring of vasospasm i ...
The hippocampus is injured in both hypoxia-ischemia (HI) and perinatal iron deficiency that are co-morbidities in infants of diabetic mothers and intrauterine growth restricted infants. We hypothesized that preexisting perinatal iron deficiency predisposes ...
The purpose of this study was to investigate astrocytic oxidative metabolism using 1-(11)C-acetate. 1-(11)C-acetate kinetics were evaluated in the rat somatosensory cortex using a beta-scintillator during different manipulations (test-retest, infraorbital ...
WE USED A MURINE MODEL OF TRANSIENT FOCAL CEREBRAL ISCHEMIA TO STUDY: 1) in vivo DTI long-term temporal evolution of the apparent diffusion coefficient (ADC) and diffusion fractional anisotropy (FA) at days 4, 10, 15 and 21 after stroke 2) ex vivo distribu ...
It is well established that lactate can be used as an energy substrate by the brain by conversion to pyruvate and a subsequent oxidation in the mitochondria. Knowing the need for readily metabolizable substrates directly after ischemia and the protective e ...
22q11.2 deletion syndrome (22q11.2DS) is a common genetic condition associated with cognitive and learning impairments. In this study, we applied a threedimensional method for quantifying gyrification at thousands of points over the cortical surface to ima ...
