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Simultaneous Chemical Recording and Stimulation in the Brain Using an Assembly of Biosensor Silicon Microprobes and SU-8 Microinjectors

Publications associées (43)

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Real-time monitoring of glutamate, being the primary excitatory neurotransmitter, is of utmost importance for understanding the functioning of the central nervous system. Since expected concentrations and its variation in the brain are in the range of 0.5 ...

2010

Simultaneous Chemical Recording and Stimulation in the Brain Using an Assembly of Biosensor Silicon Microprobes and SU-8 Microinjectors

Nico de Rooij, Peter Van der Wal, Olivier Frey

In this contribution we present multi-channel microinjector arrays fabricated by a reliable three-layer SU-8 process and assembled with glutamate biosensor microprobes'. It enables local delivery of specific liquids into brain tissue for the stimulation or ...

Elsevier Science, Reg Sales Off, Customer Support Dept, 655 Ave Of The Americas, New York, Ny 10010 Usa2009

Spatial heterogeneity of functional Magnetic Resonance Imaging indices of dorsolateral prefrontal cortex activation evoked by a working memory task: A comparison of patients with schizophrenia and healthy controls

Background: This study is based on the hypothesis that functional Magnetic Resonance Imaging (fMRI) indices in the dorsolateral prefrontal cortex (DLPFC) of schizophrenia patients are spatially more heterogeneous than healthy controls for activation evoked ...

2009

Three sequential brain activations encode mental transformations of upright and inverted human bodies: a high resolution evoked potential study

Olaf Blanke

Human bodies provide a particularly rich source of visual information. Whereas most previous studies have focused on the neural mechanisms during the perception and recognition of human bodies, the aim of the present study was to investigate the time cours ...

Elsevier2009

Clathrin-dependent endocytosis is mediated by a tightly regulated network of molecular interactions that provides essential protein-protein and protein-lipid binding activities. Here we report the hydrolysis of the alpha- and beta2-subunits of the tetramer ...

American Society for Biochemistry and Molecular Biology2009

Investigating signal integration with canonical correlation analysis of fMRI brain activation data

Kerstin Preuschoff

How the brain integrates signals from specific areas has been a longstanding critical question for neurobiologists. Two recent observations suggest a new approach to fMRI data analysis of this question. First, in many instances, the brain analyzes inputs b ...

2008

The complexity of processes occurring in the brain is an intriguing issue not just for scientists and medical doctors, but the humanity in general. The cortex ability to perceive and analyze an enormous amount of information in an instance of time, the par ...

EPFL2008

The neural cell adhesion molecule (NCAM) has been implicated in regulating synaptic plasticity mechanisms as well as memory consolidation processes. Attachment of polysialic acid to NCAM (PSA-NCAM) has been reported to down-regulate its adhesive forces, a ...

2007

The role of the amygdala in emotional memories

Maria del Carmen Sandi Perez, Kamila Markram

This thesis investigates the role of the amygdala for the establishment of fear memories with a multidisciplinary approach, including behavioural, psychopharmacological, genetic, molecular, and electrophysiological techniques in rats or mice, under healthy ...

EPFL2007

Whole-brain glutamate metabolism evaluated by steady-state kinetics using a double-isotope procedure: effects of gabapentin

Rolf Gruetter

Cerebral rates of anaplerosis are known to be significant, yet the rates measured in vivo have been debated. In order to track glutamate metabolism in brain glutamatergic neurons and brain glia, for the first time unrestrained awake rats were continuously ...

Wiley-Blackwell2004