Static compression of articular cartilage can reduce solute diffusivity and partitioning: implications for the chondrocyte biological response
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Ligands that specifically bind to articular cartilage tissues are disclosed, including uses for targeting therapeutics towards articular cartilage tissue and new materials for articular cartilage. The ligands are effective in vivo to target therapeutic mat ...
Articular cartilage plays important roles in weight-bearing, lubrication, and load distribution in articulating joints. The tissue is mostly extracellular matrix (>90% by volume) that is synthesized and remodeled by cells (chondrocytes) embedded within. Ad ...
The chondrocytes of adult articular cartilage rely upon transport phenomena within their avascular extracellular matrix for many biological activities. Therefore, changes in matrix structure which influence cytokine transport parameters may be an important ...
Injuries to the meniscus are often treated by partial or total meniscectomy, which is known to be associated with detrimental changes in joint function, ultimately increasing the risk of early degenerative joint diseases. Surgical approaches currently in u ...
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