Publication
Studies of UV-inducible promoters from Clostridium perfringens in vivo and in vitro
Publications associées (39)
Computational identification and experimental characterization of preferred downstream positions in human core promoters
Author summary Transcription of genes by the RNA polymerase II enzyme initiates at a genomic region termed the core promoter. The core promoter is a regulatory region that may contain diverse short DNA sequence motifs/elements that confer specific properti ...
PUBLIC LIBRARY SCIENCE2021The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity
Biogenesis of eukaryotic box C/D small nucleolar ribonucleoproteins initiates co-transcriptionally and requires the action of the assembly machinery including the Hsp90/R2TP complex, the Rsa1p:Hit1p heterodimer and the Bcd1 protein. We present genetic inte ...
NATURE RESEARCH2021Oscillating and stable genome topologies underlie hepatic physiological rhythms during the circadian cycle
Felix Naef, Jake Yeung, Jérôme Mermet
The circadian clock drives extensive temporal gene expression programs controlling daily changes in behavior and physiology. In mouse liver, transcription factors dynamics, chromatin modifications, and RNA Polymerase II (PolII) activity oscillate throughou ...
2021Human T-Cell Lymphotropic Virus Type 1 Transactivator Tax Exploits the XPB Subunit of TFIIH during Viral Transcription
Human T-cell lymphotropic virus type 1 (HTLV-1) Tax oncoprotein is required for viral gene expression. Tax transactivates the viral promoter by recruiting specific transcription factors but also by interfering with general transcription factors involved in ...
AMER SOC MICROBIOLOGY2020KAP1 targets actively transcribed genomic loci to exert pleomorphic effects on RNA polymerase II activity
Didier Trono, Evaristo Jose Planet Letschert, Marco Cassano, Annamaria Kauzlaric, Suk Min Jang
KAP1 (KRAB-associated protein 1) is best known as a co-repressor responsible for inducing heterochromatin formation, notably at transposable elements. However, it has also been observed to bind the transcription start site of actively expressed genes. To a ...
2020Computational study of transcription factor binding sites
Any living organism contains a whole set of instructions encoded as genes on the DNA. This set of instructions contains all the necessary information that the organism will ever need, from its development to a mature individual to environment specific resp ...
EPFL2020RDHK Family, Regulators dedicated to Organohalide Respiration - Sequence Diversity and Functional Prediction
Christof Holliger, Julien Maillard, Mathilde Stéphanie Willemin
Organohalide respiration (OHR) is an anaerobic metabolism by which bacteria conserve energy from the use of organohalide molecules as terminal electron acceptors. Because most organohalides of anthropogenic origin are persistent pollutants, the study of ba ...
2019RDHK Family, Regulators dedicated to Organohalide Respiration - Sequence Diversity and Functional Prediction
Christof Holliger, Julien Maillard, Mathilde Stéphanie Willemin
Organohalide respiration (OHR) is an anaerobic metabolism by which bacteria conserve energy from the use of organohalide molecules as terminal electron acceptors. Because most organohalides of anthropogenic origin are persistent pollutants, the study of ba ...
2019Differential regulation of RNA polymerase III genes during liver regeneration
Olivier Martin, Bart Deplancke, Felix Naef, Jacques Rougemont, Nicolas Jean Philippe Guex, Marion Leleu, Fabrice David, Winship Herr, Mauro Delorenzi, Kyle Gustafson, Dominic Villeneuve, Cristian Carmeli, Sunil Kumar Raghav, Nouria Hernandez, Laura Symul, Irina Krier, Julien Delafontaine, Philippe Jacquet, Julia Catharina Cajan, Maykel Lopes, Ioannis Xenarios, François Mange
Mouse liver regeneration after partial hepatectomy involves cells in the remaining tissue synchronously entering the cell division cycle. We have used this system and H3K4me3, Pol II and Pol III profiling to characterize adaptations in Pol III transcriptio ...
Oxford University Press (OUP)2019Modeling and analysis of parts and devices of genetic regulation
DNA encrypts the composition of the cellular material that is synthesized through transcription and translation. Never-theless, gene regulation mechanisms determine the final amount of transcribed and translated material. Transcription factors (TF) are a c ...
EPFL2018