Potential novel drug carriers for inner ear treatment: hyperbranched polylysine and lipid nanocapsules
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A new hearing therapy based on direct acoustic cochlear stimulation was developed for the treatment of severe to profound mixed hearing loss. The device efficacy was validated in an initial clinical trial with four patients. This semi-implantable investiga ...
Institute of Electrical and Electronics Engineers2011
In pre-hearing mice, vesicle exocytosis at cochlear inner hair cell (IHC) ribbon synapses is triggered by spontaneous Ca2+ spikes. At the onset of hearing, IHC exocytosis is then exclusively driven by graded potentials, and is characterized by higher Ca2+ ...
A new hearing therapy called Direct Acoustical Cochlear Stimulation (DACS) was developed and validated in a first clinical trial with four patients. The key component of this therapy based on an implantable hearing device is a micro-actuator that is implan ...
A new hearing therapy called Direct Acoustical Cochlear Stimulation (DACS) was developed and validated in a first clinical trial with four patients. The key component of this therapy based on an implantable hearing device is a micro-actuator that is implan ...
Extending previous works done on considerably smaller data sets, the paper studies linear discriminant analysis of about 30 hours of phoneme-labeled speech data in the time-frequency domain. Analysis is carried both independently in time and frequency and ...
Tinnitus, the chronic perception of ringing or other phantom sounds, is typically associated with hearing loss. Recent studies in mouse models have alleviated tinnitus symptom by reversing plastic reorganization observed in the tonotopic maps of primary au ...
To address the requirement for lymphatic capillaries in dendritic cell (DC) mobilization from skin to lymph nodes (LNs), we used mice bearing one inactivated allele of vascular endothelial growth factor receptor 3 (VEGFR3) where skin lymphatic capillaries ...
Sensorineural hearing loss is the most common type of hearing loss worldwide, yet the underlying cause is typically unknown because the inner ear cannot be biopsied today without destroying hearing, and intracochlear cells have not been imaged with resolut ...
This paper introduces high-quality audio coding using psychoacoustic models. This technology is now abundant, with gadgets named after a standard (mp3 players) and the ability to play high-quality audio from literally billions of devices. The usual paradig ...
Nowadays, hearing impaired people can be treated with a multitude of different devices and surgical interventions that are selected in function of the type and degree of hearing loss of the patient. These known therapies cover the major part of possible he ...
