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Lensless high-resolution on-chip optofluidic microscopes for Caenorhabditis elegans and cell imaging

Publications associées (55)

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Simultaneous measurement of liquid absorbance and refractive index using a compact optofluidic probe

Maurine Malak Karam Awadallah

We present a novel optical technique for simultaneously measuring the absorbance and the refractive index of a thin film using an infrared optofluidic probe. Experiments were carried on two different liquids and the results agree with the bibliographical d ...

Royal Society of Chemistry2013

Understanding the fundamental properties of electrochemical systems, especially at the microscopic level, requires advanced tools combining electrochemical microscopy and scanning probe techniques with mathematical modeling for the quantification of the ph ...

EPFL2013

Switchable telescopic contact lens

We present design and first demonstration of optics for a telescopic contact lens with independent optical paths for switching between normal and magnified vision. The magnified optical path incorporates a telescopic arrangement of positive and negative an ...

Optical Soc Amer2013

Wafer bonding using parylene-C to Si, SiO2 and SiN surfaces has recently been shown to enable high pressure-resistant microfluidic devices with metallization and CMOS-integration capability. Here, we report characterization of intermediate parylene-C bondi ...

2012

Optofluidic differential spectroscopy for absorbance detection of sub-nanolitre liquid samples

Wuzhou Song, Jianhang Yang

We present a novel optofluidic differential method for carrying out absorbance spectroscopy of subnanolitre volumes of liquid samples on a microfluidic chip. Due to the reduction of liquid volume, the absorbance detection in microfluidics is often hindered ...

Royal Society of Chemistry2012

Large-scale Plasmonic Microarray: A New Approach for Label-free High-throughput Biosensing and Screening

Hatice Altug, Serap Aksu, Min Huang

We present a large-scale label-free microarray with over one million plasmonic nanohole array sensors on a microscope slide. A dual-color filter imaging method is invented to dramatically increase the sensor performance in a highly-multiplexed manner. ...

IEEE2012

The physiological properties of cells are typically investigated in ensembles yielding averaged data that mask heterogeneities present in any cell population. Single-cell analysis techniques based on microfluidic "lab on a chip" (LOC) devices have recently ...

EPFL2011

Optofluidic membrane interferometer: An imaging method for measuring microfluidic pressure and flow rate simultaneously on a chip

Demetri Psaltis, Wuzhou Song

We present a novel image-based method to measure the on-chip microfluidic pressure and flow rate simultaneously by using the integrated optofluidic membrane interferometers (OMIs). The device was constructed with two layers of structured polydimethylsiloxa ...

American Institute of Physics2011

Microfluidic array cytometer based on refractive optical tweezers for parallel trapping, imaging and sorting of individual cells

René Salathé, Horst Vogel, Fabrice Merenda, Joachim Piguet, Michael Werner

Analysis of genetic and functional variability in populations of living cells requires experimental techniques capable of monitoring cellular processes such as cell signaling of many single cells in parallel while offering the possibility to sort interesti ...

Royal Society of Chemistry2011

Sub-micron channels fabricated by direct electron beam lithography on SU8 for optofluidic bacterial analysis

Demetri Psaltis, Andreas Vasdekis

Microfluidic structures in poly(dimethylsiloxane) (PDMS) are usually fabricated by optically patterning a resist and subsequently transferring this pattern to PDMS. Such microsystems suffer from reduced resolution, which in turn inhibit the manipulation of ...

Spie-Int Soc Optical Engineering, Po Box 10, Bellingham, Wa 98227-0010 Usa2011