A highly stereoselective synthesis of (2S, 3S)-beta -hydroxyleucine

Jieping Zhu
1997
Article

Résumé

An efficient asym. synthesis of (2S,3S)-beta -hydroxyleucine is described. The key step in the synthesis was a highly diastereoselective nucleophilic addn. of Grignard reagent to N,N-dibenzyl-O-TBS-serinal (TBS = SiMe2CMe3). This strategy should be applicable to the synthesis of other related beta -hydroxy amino acids. [on SciFinder (R)]

Source officielle

https://infoscience.epfl.ch/record/158187?ln=fr

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