H-1 NMR spectroscopy of rat brain in vivo at 14.1 Tesla: Improvements in quantification of the neurochemical profile
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Nuclear magnetic resonance (NMR) spectroscopy can be applied in vivo to measure static or dynamic biochemical information, e.g., concentrations of metabolites and metabolic fluxes, using various nuclei such as 1H, 13C, 31P and 15N. The work of this thesis ...
We measure by inelastic neutron scattering the spin excitation spectra as a function of applied magnetic field in the quantum spin-ladder material (C5H12N)(2)CuBr4. Discrete magnon modes at low fields in the quantum disordered phase and at high fields in t ...
Proton magnetic resonance spectroscopy (1H-MRS) has been used in a number of studies to noninvasively assess the temporal changes of lactate in the activated human brain. However, the results have not been consistent. The aim of the present study was to te ...
An important development in the field of NMR spectroscopy has been the advent of hyperpolarization approaches, capable of yielding nuclear spin states whose value exceeds by orders-of-magnitude what even the highest-field spectrometers can afford under Bol ...
Despite obvious improvements in spectral resolution at high magnetic field, the detection of C-13 labeling by H-1-[C-13] NMR spectroscopy remains hampered by spectral overlap, such as in the spectral region of H-1 resonances bound to C3 of glutamate (Glu) ...
Developments towards an understanding of the nature of conductance at the interface between two different metallic layers – ferromagnetic and non magnetic – as well as the discovery of giant magnetoresistance have stirred attention from both the scientific ...
Reliable quantification of the macromolecule signals in short echo-time H-1 MRS spectra is particularly important at high magnetic fields for an accurate quantification of metabolite concentrations (the neurochemical profile) due to effectively increased s ...
Microfabricated probes for Nuclear Magnetic Resonance (NMR) spectroscopy of living cells in very small quantities have been developed in this thesis. These microprobes are based on two different sample interfaces: Channel microprobes, which confine a stack ...
Proton spectroscopy allows the simultaneous quantification of a high number of metabolite concentrations termed the neurochemical profile. The spin echo full intensity acquired localization (SPECIAL) scheme with an echo time of 2.7 ms was used at 9.4T for ...
In in vivo H-1 spectroscopy, the signal at 1.32 ppm is usually assigned to lactate. This resonance position is shared with threonine at physiological pH. The similarity of spectral patterns of lactate and threonine renders the separate measurement of eithe ...