Publication
Simultaneous sample washing and concentration using a “trapping-and-releasing” mechanism of magnetic beads on a microfluidic chip
Publications associées (34)
Microfluidic devices
The present disclosure relates to a microfluidic device comprising: a substrate; a culture chamber (130); a loading channel (170) in fluid communication with the culture chamber; at least one auxiliar channel (170-1, 5 170-2) extending from and in fluid co ...
2023Studying the roundworm Caenorhabditis elegans using microfluidic chips
C. elegans is an attractive model organism in biology, as it shows genetic similarity with humans, facilitates microscopic observation due to its transparency, and has a short life cycle. Moreover, many mutants expressing fluorescent proteins in particular ...
SPIE-INT SOC OPTICAL ENGINEERING2019Quantitative chemical biosensing by bacterial chemotaxis in microfluidic chips
Harald Van Lintel, Jan Roelof van der Meer, Clémence Roggo
Whole-cell bacterial bioreporters are proposed asalternatives to chemical analysis of, for example, pol-lutants in environmental compartments. Commonlybased on reporter gene induction, bioreporters pro-duce a detectable signal within 30 min to a few hoursa ...
Wiley-Blackwell2018Lab-on-a-chip technologies for manipulation and imaging of C. elegans worms and embryos
The nematode Caenorhabditis elegans is an attractive model organism, owing notably to its short life cycle, genetic tractability, and optical transparency facilitating microscopic observation. This thesis deals with the realization of technological tools f ...
EPFL2018A Simple and Reliable PDMS and SU-8 Irreversible Bonding Method and Its Application on a Microfluidic-MEA Device for Neuroscience Research
Philippe Renaud, Arnaud Bertsch, Marc Olivier Heuschkel, Patrick Fraering, Sébastien Mosser, Yufei Ren, Shun-Ho Huang, Jingjing Chen
Polydimethylsiloxane (PDMS) and SU-8 are currently two very commonly used polymeric materials in the microfluidics field for biological applications. However; there is a pressing need to find a simple, reliable, irreversible bonding method between these tw ...
MDPI2015Dose-response curve of a microfluidic magnetic bead-based surface coverage sandwich assay
Martinus Gijs, Thomas Lehnert, Matteo Cornaglia, Raphaël Etienne Jean Trouillon, Hüseyin Cumhur Tekin
Magnetic micro-and nanoparticles ('magnetic beads') have been used to advantage in many microfluidic devices for sensitive antigen (Ag) detection. Today, assays that use as read-out of the signal the number count of immobilized beads on a surface for quant ...
Elsevier2015Foil-Level Inkjet-Printed pyroMEMS Balloon Actuators: Fabrication, Modeling, and Validation
Nico de Rooij, Danick Briand, Francisco Molina Lopez, David de Koninck
A cleanroom-free fabrication process adapted to microfluidic devices is presented for pyrotechnical microelectromechanical systems balloon actuators. The actuators are intended for on-chip pumping and fluid ejection to replace tabletop pumping solutions in ...
Institute of Electrical and Electronics Engineers2014Programming and use of Parylene C fluorescence as a quantitative on-chip reference
Martinus Gijs, Diego Gabriel Dupouy, Ata Tuna Ciftlik, Joan Teixidor
A large number of lab-on-a-chip applications use fluorescence for quantifying biological entities. In such applications, incorporation of a stable on-chip fluorescent reference source would be highly desirable in order to compensate for instrumental parame ...
Royal Soc Chemistry2014Attomolar protein detection using a magnetic bead surface coverage assay
Martinus Gijs, Matteo Cornaglia, Hüseyin Cumhur Tekin
We demonstrate a microfluidic method for ultra-sensitive protein detection in serum. First, ‘large’ (2.8 μm) antibody-functionalized magnetic beads specifically capture antigen from a serum matrix under active microfluidic mixing. Subsequently, the large b ...
Royal Society of Chemistry2013Programmable parylene-C bonding layer fluorescence for storing information on microfluidic chips
Martinus Gijs, Diego Gabriel Dupouy, Ata Tuna Ciftlik
We demonstrate data storage on glass/silicon microfluidic devices fabricated using parylene-C as a bonding layer. In particular, we report intermediate parylene-C bonding layer fluorescence (iPBLF) and its use as an on-chip medium for data storage by dynam ...
Royal Society of Chemistry2013