Chromosome 15 humainLe chromosome 15 est un des 24 chromosomes humains. C'est l'un des 22 autosomes et l'un des 5 chromosomes acrocentriques. Nombre de paires de base : Nombre de gènes : 766 Nombre de gènes connus : 589 Nombre de pseudo gènes : 308 Nombre de variations des nucléotides (S.N.P ou single nucleotide polymorphisme) : Syndrome de Prader-Willi Syndrome d'Angelman On trouve, entre autres, sur le chromosome 15 : le gène EYCL3 codant, en partie, la couleur des yeux et dont on distingue deux allèles.
Virtual karyotypeVirtual karyotype is the digital information reflecting a karyotype, resulting from the analysis of short sequences of DNA from specific loci all over the genome, which are isolated and enumerated. It detects genomic copy number variations at a higher resolution for level than conventional karyotyping or chromosome-based comparative genomic hybridization (CGH). The main methods used for creating virtual karyotypes are array-comparative genomic hybridization and SNP arrays.
Leucémie aiguë promyélocytaireLa leucémie aiguë promyélocytaire (LAP) est un sous-type de leucémie aiguë myéloïde. Elle est caractérisée par une prolifération de cellules immatures résultant d'un blocage de maturation des polynucléaires au stade de promyélocyte. Elle constitue une des entités dans la classification OMS des LAM de 2016 sous le nom leucémie aiguë promyélocytaire avec PML-RARA; dans l'ancienne classification FAB elle correspond à la LAM3. Elle fait partie des cancers où a été identifiée une anomalie génétique constante à l'origine de la maladie.
Eosinophilic pneumoniaEosinophilic pneumonia is a disease in which an eosinophil, a type of white blood cell, accumulates in the lungs. These cells cause disruption of the normal air spaces (alveoli) where oxygen is extracted from the atmosphere. Several different kinds of eosinophilic pneumonia exist and can occur in any age group. The most common symptoms include cough, fever, difficulty breathing, and sweating at night. Eosinophilic pneumonia is diagnosed by a combination of characteristic symptoms, findings on a physical examination by a health provider, and the results of blood tests and X-rays.
Eosinophilic myocarditisEosinophilic myocarditis is inflammation in the heart muscle that is caused by the infiltration and destructive activity of a type of white blood cell, the eosinophil. Typically, the disorder is associated with hypereosinophilia, i.e. an eosinophil blood cell count greater than 1,500 per microliter (normal 100 to 400 per microliter). It is distinguished from non-eosinophilic myocarditis, which is heart inflammation caused by other types of white blood cells, i.e.
Lymphocyte-variant hypereosinophiliaLymphocyte-variant hypereosinophilia is a rare disorder in which eosinophilia or hypereosinophilia (i.e. a large or extremely large increase in the number of eosinophils in the blood circulation) is caused by an aberrant population of lymphocytes. These aberrant lymphocytes function abnormally by stimulating the proliferation and maturation of bone marrow eosinophil-precursor cells termed colony forming unit-Eosinophils or CFU-Eos.
Interleukine 33L'interleukine 33, ou IL-33, est une interleukine appartenant à la famille des interleukines 1. L'IL-33 est un puissant inducteur des réponses immunitaires T helper (Th) 2, et est un médiateur important pour la cicatrisation des muqueuses et la restauration / réparation épithéliale . Le complexe forme de IL-33 avec son récepteur ST2 peut également favoriser les réponses de type Th1 en fonction de la présence ou de l'absence d'IL-12 .
Ethics of cloningIn bioethics, the ethics of cloning refers to a variety of ethical positions regarding the practice and possibilities of cloning, especially human cloning. While many of these views are religious in origin, some of the questions raised by cloning are faced by secular perspectives as well. Perspectives on human cloning are theoretical, as human therapeutic and reproductive cloning are not commercially used; animals are currently cloned in laboratories and in livestock production.
Clonal hypereosinophiliaClonal hypereosinophilia, also termed primary hypereosinophilia or clonal eosinophilia, is a grouping of hematological disorders all of which are characterized by the development and growth of a pre-malignant or malignant population of eosinophils, a type of white blood cell that occupies the bone marrow, blood, and other tissues. This population consists of a clone of eosinophils, i.e. a group of genetically identical eosinophils derived from a sufficiently mutated ancestor cell.
Dysplastic nevusA dysplastic nevus or atypical mole is a nevus (mole) whose appearance is different from that of common moles. In 1992, the NIH recommended that the term "dysplastic nevus" be avoided in favor of the term "atypical mole". An atypical mole may also be referred to as an atypical melanocytic nevus, atypical nevus, B-K mole, Clark's nevus, dysplastic melanocytic nevus, or nevus with architectural disorder. Dysplastic nevi often grow to larger than ordinary moles and may have irregular and indistinct borders.
