Publication
Photodynamic therapy for early squamous cell carcinomas of the esophagus, bronchi, and mouth with m-tetra(hydroxyphenyl) chlorin
Publications associées (48)
Molecular screening of cancer-derived exosomes by surface plasmon resonance spectroscopy
Horst Vogel, Niels Erik Lion, Davide Demurtas, Luigino Grasso, Michel Prudent, Romain Wyss, Ashwin Thampi, Lorenz Weidenauer
We report on a generic method to detect and iden- tify the molecular profile of exosomes either derived from cultured cell lines or isolated from biofluids. Exosomes are nanovesicles shed by cells into their microenvironment and carry the molecular identit ...
Springer Heidelberg2015Functionalization of Nanoparticles for Targeted Cancer Imaging and Diagnosis
Solène Marcelle Françoise Marie Passemard
At present time, cancer is the leading cause of death in developed countries. The medical imaging tools currently used in clinics such as radiology, nuclear magnetic resonance imaging, microscopy and endoscopy are not able to reach the sensitivity necessar ...
EPFL2014No benefit from combining HE4 and CA125 as ovarian tumor markers in a clinical setting
Objective. About 70% of epithelial ovarian cancer patients (EOC) are diagnosed at advanced stage with a five-year survival rate of only 30%. Whilst CA125 detects peritoneally-spread disease, it has limited sensitivity for early cancers, many of which are p ...
2011Studies toward new anti-cancer strategies based on alpha-mannosidase inhibition
Changes in the glycosylation pattern of cellular glycoproteins constitute a hallmark in human cancer and influence tumour progression, suggesting that inhibitors of selected glycosidases may control cancer invasion. Following the studies on swainsonine, a ...
Schweizerische Chemische Gesellschaft2010Detection of early bladder carcinoma by fluorescence cystoscopy with Hexvix(R): Improvement of the specificity by microcystoscopy
Hubert van den Bergh, Georges Wagnières, Blaise Lovisa
Our long-term activity in the development of fluorescence imaging for the detection of early superficial bladder cancer aimed at optimizing the selective production and accumulation of photoactivable porphyrins (PaP), mainly protoporphyrin IX (PpIX), after ...
2008Ruthenium Porphyrin Compounds for Photodynamic Therapy of Cancer
Paul Joseph Dyson, Wee Han Ang, Frédéric Schmitt
Five 5,10,15,20-tetra(4-pyridyl)porphyrin (TPP) areneruthenium(II) derivs., a p-cymeneosmium, a pentamethylcyclopentadienyliridium and a pentamethylcyclopentadienylrhodium analog were prepd. and characterized as potential photosensitizing chemotherapeutic ...
2008Optimalisation de la photothérapie dynamique et de la photodétection de cancers précoces par spectroscopie résolue en temps de luminophores endogènes et exogènes
The aim of this thesis is to optimize and obtain fundamental information on i) the photodetection (PD) of early stage cancers in the tracheo-bronchial tree by spectroscopic imaging of the tissue autofluorescence, ii) photodynamic therapy (PDT) applied in d ...
EPFL2004In vivo autofluorescence imaging of early cancers in the human tracheobronchial tree with a spectrally optimized system
Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger
The changes in the autofluorescence characteristics of the bronchial tissue is of crucial interest as a cancer diagnostic tool. Evidence exists that this native fluorescence or autofluorescence of bronchial tissues changes when they turn dysplastic and to ...
2003Optimization of the spectral design used to detect early carcinoma in the human tracheo-bronchial tree by autofluorescence imaging
Hubert van den Bergh, Georges Wagnières, Tanja Gabrecht
The early detection and localization of bronchial cancer remains a challenging task. Autofluorescence bronchoscopy is emerging as a useful diagnostic tool with improved sensitivity and specificity. Evidence exists that the native fluorescence or autofluore ...
2003Evolution of DNA ploidy during squamous cell carcinogenesis in the esophagus
Image and flow cytometry was used to study the nuclear DNA content (ploidy) during the squamous cell carcinogenesis in the esophagus. The present retrospective study comprised 26 surgical specimens of squamous cell carcinomas (SCC) in patients who underwen ...
2002