A modular synthesis of the marine natural product largazole and related synthetic analogs is described. Largazole was prepd. in 10% overall yield through a synthetic route with a longest linear sequence of nine steps. Activity tests showed the necessity of the thiobutenyl moiety for antiproliferative activity.
Philipp Georg Werner Seeberger
Qian Wang, Jieping Zhu, Takuji Fujii, Simone Gallarati
Viktor Kuncak, Mikaël Mayer, Philippe Paul Henri Suter, Ruzica Piskac