Publication
Labeled acetate as a marker of astrocytic metabolism
Publications associées (33)
A two-compartment mathematical model of neuroglial metabolism using [1-C-11] acetate
The purpose of this study was to develop a two-compartment metabolic model of brain metabolism to assess oxidative metabolism from [1-C-11] acetate radiotracer experiments, using an approach previously applied in C-13 magnetic resonance spectroscopy (MRS), ...
Nature Publishing Group2012VGLUT1 is localized in astrocytic processes in several brain regions
During the last years, the concept of gliotransmission has been established. Glutamate has been shown to be released from astrocytes by different mechanisms, e.g., in an exocytotic manner. The authors have previously shown that astrocytes in the dentate-mo ...
2012Stimulation-induced increases of astrocytic oxidative metabolism in rats and humans investigated with 1-11C-acetate
Pierre Magistretti, Luc Pellerin
The purpose of this study was to investigate astrocytic oxidative metabolism using 1-(11)C-acetate. 1-(11)C-acetate kinetics were evaluated in the rat somatosensory cortex using a beta-scintillator during different manipulations (test-retest, infraorbital ...
2008Neuroglial metabolism in the awake rat brain: CO2 fixation increases with brain activity
Glial cells are thought to supply energy for neurotransmission by increasing nonoxidative glycolysis; however, oxidative metabolism in glia may also contribute to increased brain activity. To study glial contribution to cerebral energy metabolism in the un ...
2004