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Publication# Extraction of network topology from multi-electrode recordings: is there a small-world effect?

Résumé

The simultaneous recording of the activity of many neurons poses challenges for multivariate data analysis. Here, we propose a general scheme of reconstruction of the functional network from spike train recordings. Effective, causal interactions are estimated by fitting generalized linear models on the neural responses, incorporating effects of the neurons' self-history, of input from other neurons in the recorded network and of modulation by an external stimulus. The coupling terms arising from synaptic input can be transformed by thresholding into a binary connectivity matrix which is directed. Each link between two neurons represents a causal influence from one neuron to the other, given the observation of all other neurons from the population. The resulting graph is analyzed with respect to small-world and scale-free properties using quantitative measures for directed networks. Such graph-theoretic analyses have been performed on many complex dynamic networks, including the connectivity structure between different brain areas. Only few studies have attempted to look at the structure of cortical neural networks on the level of individual neurons. Here, using multi-electrode recordings from the visual system of the awake monkey, we find that cortical networks lack scale-free behavior, but show a small, but significant small-world structure. Assuming a simple distance-dependent probabilistic wiring between neurons, we find that this connectivity structure can account for all of the networks' observed small-world-ness. Moreover, for multi-electrode recordings the sampling of neurons is not uniform across the population. We show that the small-world-ness obtained by such a localized sub-sampling overestimates the strength of the true small-world structure of the network. This bias is likely to be present in all previous experiments based on multi-electrode recordings.

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Théorie des graphes

vignette|Un tracé de graphe.
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Système visuel humain

Le est l'ensemble des organes participant à la perception visuelle humaine, de la rétine au système sensori-moteur. Son rôle est de percevoir et d'interpréter deux images en deux dimensions en une

Publications associées (124)

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Joao Emanuel Felipe Gerhard, Wulfram Gerstner

Since the seminal work of Watts in the late 90s [1], graph-theoretic analyses have been performed on many complex dynamic networks, including brain structures [2]. Most studies have focused on functional connectivity defined between whole brain regions, using imaging techniques such as fMRI, EEG or MEG. Only very few studies have attempted to look at the structure of neural networks on the level of individual neurons [3,4]. To the best of our knowledge, these studies have only considered undirected connectivity networks and have derived connectivity based on estimates on small subsets or even pairs of neurons from the recorded networks.Here, we investigate scale-free and small-world properties of neuronal networks, based on multi-electrode recordings from the awake monkey on a larger data set than in previous approaches. We estimate effective, i.e. causal, interactions by fitting Generalized Linear Models on the neural responses to natural stimulation. The resulting connectivity matrix is directed and a link between two neurons represents a causal influence from one neuron to the other, given the observation of all other neurons from the population. We use this connectivity matrix to estimate scale-free and small-world properties of the network samples. For this, the quantity proposed by Humphries et al. (2008) for quantifying small-world-ness is generalized to directed networks [5]. We find that the networks under consideration lack scale-free behavior, but show a small, but significant small-world structure.Finally, we show that the experimental design of multi-electrode recordings typically enforces a particular network structure that can have a considerate impact on how the small-world structure of the network should be evaluated. Random graphs that take the geometry of the experiment into account can serve as a more refined null model than the homogeneous random graphs that are usually proposed as reference models to evaluate small-world properties. References [1] Watts, D. J., Strogatz, S. H., 1998. Collective dynamics of 'small-world' networks. Nature 393 (6684), 440-442. [2] Bullmore, E., & Sporns, O. (2009). Complex brain networks: graph theoretical analysis of structural and functional systems. Nature Reviews Neuroscience, 10(3), 186–198. [3] Bettencourt, L. M. A., Stephens, G. J., Ham, M. I., Gross, G. W., 2007. Functional structure of cortical neuronal networks grown in vitro. Physical Review E 75 (2), 021915+. [4] Yu, S., Huang, D., Singer, W., Nikolic, D., 2008. A small world of neuronal synchrony. Cereb. Cortex, bhn047+. [5] Humphries, M. D., Gurney, K., April 2008. Network 'small-world-ness': a quantitative method for determining canonical network equivalence. PloS one 3 (4), e0002051+.

2010Joao Emanuel Felipe Gerhard, Wulfram Gerstner

Since the seminal work of Watts in the late 90s, graph-theoretic analyses have been performed on many complex dynamic networks, including brain structures. Most studies have focused on functional connectivity defined between whole brain regions, using imaging techniques such as fMRI, EEG or MEG. Only very few studies have attempted to look at the structure of neural networks on the level of individual neurons. To the best of our knowledge, these studies have only considered undirected connectivity networks and have derived connectivity based on estimates on small subsets or even pairs of neurons from the recorded networks. Here, we investigate scale-free and small-world properties of neuronal networks, based on multi-electrode recordings from the awake monkey on a larger data set than in previous approaches. We estimate effective, i.e. causal, interactions by fitting Generalized Linear Models on the neural responses to natural stimulation. The resulting connectivity matrix is directed and a link between two neurons represents a causal influence from one neuron to the other, given the observation of all other neurons from the population. We use this connectivity matrix to estimate scale-free and small-world properties of the network samples. For this, the quantity proposed by Humphries et al. (2008) for quantifying small-world-ness is generalized to directed networks. We find that the networks under consideration lack scale-free behavior, but show a small, but significant small-world structure. Finally, we show that the experimental design of multi-electrode recordings typically enforces a particular network structure that can have a considerate impact on how the small-world structure of the network should be evaluated. Random graphs that take the geometry of the experiment into account can serve as a more refined null model than the homogeneous random graphs that are usually proposed as reference models to evaluate small-world properties.

2011Joao Emanuel Felipe Gerhard, Wulfram Gerstner

Since the seminal work of Watts & Strogatz and others in the late 90s [1], graph-theoretic analyses have been performed on many complex dynamic networks, including brain structures. Most studies have focused on functional connectivity defined between whole brain regions, using imaging techniques such as fMRI, EEG or MEG [2]. Only very few studies have attempted to look at the structure of neural networks on the level of individual neurons [3,4]. To the best of our knowledge, these studies have only considered undirected connectivity networks and have derived connectivity based on estimates on small subsets or even pairs of neurons from the recorded networks. Here, we investigate scale-free and small-world properties of neuronal networks, based on multi-electrode recordings from the awake monkey on a larger data set than in previous approaches. We estimate effective, i.e. causal, interactions by fitting Generalized Linear Models on the neural responses to natural stimulation, incorporating effects from the neurons’ self-history, coupling terms and modulation by the external stimulus. The resulting connectivity matrix is directed and a link between two neurons represents a causal influence from one neuron to the other, given the observation of all other neurons from the population. We use this connectivity matrix to estimate scale-free and small-world properties of the network samples. For this, the quantity proposed by [5] for quantifying small-world-ness is generalized to directed networks. We find that the networks under consideration lack scale-free behavior, but show a small, but significant small-world structure. Finally, we show that the experimental design of multi-electrode recordings typically enforces a particular network structure that can have a considerate impact on how the small-world structure of the network should be evaluated. Since for multi-electrode recordings the sampling of neurons is not uniform across the population (one electrode usually captures signals from a small local population), we expect the wiring probability between neurons of the same local spot to be much higher than the wiring probability between neurons from different electrodes. Thus, random graphs that take the different wiring probabilities into account can serve as a more refined null model than the homogeneous Erdös-Renyi random graphs that are usually proposed as reference models to evaluate small-world properties. Moreover, as the set of recorded neurons in a given experiment always represents only a subpopulation of the overall network, we investigate how the evaluation of small-world structure is affected by this undersampling bias.

2011