Notch signaling mediates embryonic vascular development and normal vascular remodeling; Notch1 knockout mice develop nodular regenerative hyperplasia (NRH). The pathogenesis of NRH is unclear, but has been associated with vascular injury in the liver sinusoids in clinical studies. We investigated the role of Notch1 signaling in liver sinusoidal endothelial cells (LSECs).
Jeffrey Alan Hubbell, Mikaël Martino, Priscilla Suhasna Maithili Briquez
Georges Wagnières, Jaroslava Joniová, Séverine Marguerite Urfer
Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez