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The neurochemical profile quantified by in vivo(1)H NMR spectroscopy

Publications associées (38)

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Mannich products of kojic acid and N-heterocycles and their Ru(II)-arene complexes: Synthesis, characterization and stability

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov

Ru(II)-η6-p-cymene compds. bearing pyrone-derived ligands, which were obtained by Mannich reactions between kojic acid and piperidine or morpholine analogs, have been synthesized. The compds. were characterized by NMR spectroscopy, mass spectrometry, therm ...

Elsevier2010

Slow dynamic processes, such as biomolecular folding/unfolding, macromolecular diffusion, etc., can be conveniently monitored by solution-state two-dimensional (2D) NMR spectroscopy, provided the inverse of their rate constants does not exceed the nuclear ...

EPFL2010

H-1-[C-13] NMR Spectroscopy of the Rat Brain During Infusion of [2-C-13] Acetate at 14.1 T

Rolf Gruetter, Lijing Xin, Bernard Lanz

Full signal intensity H-1-[C-13] NMR spectroscopy, combining a preceding C-13-editing block based on an inversion BISEP (B-1-insensitive spectral editing pulse) with a spin-echo coherence-based localization, was developed and implemented at 14.1 T. C-13 ed ...

Wiley-Blackwell2010

Improved ¹H-[¹³C] and ¹H NMR methods for in vivo measurement of cerebral metabolism

Lijing Xin

Nuclear magnetic resonance (NMR) spectroscopy can be applied in vivo to measure static or dynamic biochemical information, e.g., concentrations of metabolites and metabolic fluxes, using various nuclei such as 1H, 13C, 31P and 15N. The work of this thesis ...

EPFL2009

Chemical exchange in proteins

Mariachiara Verde

Nuclear Magnetic Resonance (NMR) spectroscopy offers many ways to investigate dynamic properties of molecules. A wide variety of experimental techniques can probe molecular dynamics on time scales that range from 10-12 to 103 seconds. Many lines of evidenc ...

EPFL2009

In order to relate the conformational dynamics of the hammerhead ribozyme to its biological function the cleavage reaction catalyzed by the hammerhead ribozyme was monitored by time-resolved nuclear magnetic resonance (NMR) spectroscopy. For this purpose, ...

2008

Progress in Hyperpolarized Ultrafast 2D NMR Spectroscopy

Mor-Miri Mishkovsky

An important development in the field of NMR spectroscopy has been the advent of hyperpolarization approaches, capable of yielding nuclear spin states whose value exceeds by orders-of-magnitude what even the highest-field spectrometers can afford under Bol ...

2008

Aerucyclamides C and D were isolated from the cyanobacterium Microcystis aeruginosa PCC 7806, and their structures established by NMR spectroscopy and chemical transformation and degradation. Acidic hydrolysis of aerucyclamide C (CF3CO2H, H2O) resulted in ...

2008

Hydrolysis study of the bifunctional antitumor compound RAPTA-C, [Ru(η6-p-cymene)Cl2(pta)]

Paul Joseph Dyson, Christian Hartinger, Claire Samantha Allardyce, Claudine Scolaro

The hydrolysis of [Ru(η6-p-cymene)Cl2(PTA)] (PTA = 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decanephosphine; RAPTA-C) was studied using UV-visible (UV-vis) spectrophotometry and NMR spectroscopy. In analogy to in silico studies, [Ru(η6-p-cymene)Cl(H2O)(PTA) ...

2008

Well-defined surface imido amido tantalum(V) species from ammonia and silica-supported tantalum hydrides

David Lyndon Emsley

The MCM-41 supported hydrides [( SiO)(2)TaH], 1a, and [( SiO)(2)TaH3], 1b, cleave N-H bonds of ammonia at room temperature to yield the well-defined imido amido surface complexes [( SiO)(2)Ta-(NH)(NH2)], 2, and 2 center dot NH3. Additionally, the surface s ...

AMER CHEMICAL SOC2007