Direct measurement of brain glucose concentrations in humans by 13C NMR spectroscopy
Graph Chatbot
Chattez avec Graph Search
Posez n’importe quelle question sur les cours, conférences, exercices, recherches, actualités, etc. de l’EPFL ou essayez les exemples de questions ci-dessous.
AVERTISSEMENT : Le chatbot Graph n'est pas programmé pour fournir des réponses explicites ou catégoriques à vos questions. Il transforme plutôt vos questions en demandes API qui sont distribuées aux différents services informatiques officiellement administrés par l'EPFL. Son but est uniquement de collecter et de recommander des références pertinentes à des contenus que vous pouvez explorer pour vous aider à répondre à vos questions.
Neural Metabolism In Vivo strives to offer a comprehensive and fundamental overview of cerebral metabolism by presenting leading-edge in vivo multimodal technology and its application in assessing neural activity, energy metabolism and neurotransmission in ...
Positron emission tomography (PET) and nuclear magnetic resonance spectroscopy (MRS) are two biomedical measurement techniques developed in the end of the XXth century, which drastically improved the amount of accessible information available in vivo. PET ...
The Krebs (or tricarboxylic acid (TCA)) cycle has a central role in the regulation of brain energy regulation and metabolism, yet brain TCA cycle intermediates have never been directly detected in vivo. This study reports the first direct in vivo observati ...
Cerebral glucose homeostasis is maintained by the equilibrium between glucose transport across the blood-brain-barrier (BBB), which occurs through facilitative carriers, and glucose consumption mainly initiated by hexokinase phosphorylation. Glucose concen ...
To maintain brain function, the combustion of glucose for the generation of energy (ATP) is essential, yet the brain maintains fuel storage in the form of glial glycogen. Although brain glycogen levels are lower than those in the liver, they exceed the nor ...
Determination of brain glucose transport kinetics in vivo at steady-state typically does not allow distinguishing apparent maximum transport rate (Tmax) from cerebral consumption rate. Using a four-state conformational model of glucose transport, we show t ...
Specialized glucosensing neurons are present in the hypothalamus, some of which neighbor the median eminence, where the blood–brain barrier has been reported leaky. A leaky blood–brain barrier implies high tissue glucose levels and obviates a role for endo ...
We present a novel microfluidic approach for on-line analysis of cell metabolism by simultaneous measurement of two important indicators (glucose and lactate) in a small volume (100 µl) of cell-culture medium. The in-vitro study of cell metabolism is espec ...
Barbiturates are regularly used as an anesthetic for animal experimentation and clinical procedures and are frequently provided with solubilizing compounds, such as ethanol and propylene glycol, which have been reported to affect brain function and, in the ...
Astrocytes have various important roles in brain physiology. To further elucidate the details of astrocytic functions under normal and pathological states, astrocyte-specific measurements are mandatory. For studying brain energy metabolism, the use of the ...