In vivo measurements of brain glucose transport using the reversible michaelis-menten model and simultaneous measurements of cerebral blood flow changes during hypoglycemia
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Mechanisms responsible for hypoglycemia unawareness remain unknown. Previously, we found that patients with type 1 diabetes and hypoglycemia unawareness had increased brain glucose concentrations as measured by (1)H-magnetic resonance spectroscopy (MRS) co ...
While chronic hypoglycaemia has been reported to increase unidirectional glucose transport across the blood-brain barrier (BBB) and to increase GLUT1 expression at the endothelium, the effect on steady-state brain d-glucose and brain glycogen content is cu ...
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[...] For many years, researchers in the biosensors field have been trying to develop a device allowing the precise measurement of the glucose level through the intact skin. In this project, an efficient device was constructed for the in-vitro impedance me ...
Aquaporin 9 facilitates the diffusion of water but also glycerol and monocarboxylates, known as brain energy substrates. AQP9 was recently observed in catecholaminergic neurons that are implicated in energy homeostasis and also possibly in neuroendocrine e ...
Oxidn.-sensitive nanoparticles have been decorated with an oxidizing enzyme (glucose oxidase) for release behavior that is responsive to the presence of the enzyme substrate (glucose). [on SciFinder (R)] ...
Cerebral rates of anaplerosis are known to be significant, yet the rates measured in vivo have been debated. In order to track glutamate metabolism in brain glutamatergic neurons and brain glia, for the first time unrestrained awake rats were continuously ...
For more than thirty years there has been a high demand for glucose measuring devices to replace the finger pricking methods and to improve the life quality of diabetics. Three approaches are possible, electrochemical, electromagnetic (including optical), ...
Hyperglycemia and diabetes alter the function and metabolism of many tissues. The effect on the brain remains poorly defined, but some animal data suggest that chronic hyperglycemia reduces rates of brain glucose transport and/or metabolism. To address thi ...