Minimal Hodgkin-Huxley type models for different classes of cortical and thalamic neurons
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Integration of multimodal information is essential for the integrative response of the brain and is thought to be accomplished mostly in sensory association areas. However, available evidences in humans and monkeys indicate that this process begins already ...
BACKGROUND: We have used a computational model of the thalamocortical system to investigate the effects of a GABAergic anesthetic (etomidate) on cerebral cortical and thalamic neuronal function. We examined the effects of phasic an tonic inhibition, as wel ...
Controversy exists regarding the site where anesthetics act in the brain to produce sedation and unconsciousness. Actions in the cerebral cortex and thalamus are likely, although the relative importance of each site is unclear. We used in computo modeling ...
Computational neuroscience is a branch of the neurosciences that attempts to elucidate the principles underlying the operation of neurons with the help of mathematical modeling. In contrast with a number of fields pursuing a tightly related goal, such as m ...
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The mammalian neocortex is one of the most complex brain areas, integrating all sensory modalities and allowing the animal to perform high level cognitive operations. Despite some cytoarchitectural specializations, the general neocortical structure is rema ...
P>The neurochemical profile of the cortex develops in a region and time specific manner, which can be distorted by psychiatric and other neurological pathologies. Pre-clinical studies often involve experimental mouse models. In this study, we determined th ...
Information received by the human cortex is supplied by two main sources: extrinsic stimuli delivered by the external environment and intrinsic information regarding the body and self. We reanalyzed electrophysiological data involving the same external sti ...
We investigated the impact of thalamus on ongoing cortical activity in the awake, behaving mouse. We demonstrate that the desynchronized cortical state during active behavior is driven by a centrally generated increase in thalamic action potential firing, ...
The general structure of the mammalian neocortex is remarkably similar across different cortical areas. Despite certain cytoarchitectural specializations and deviations from the general blueprint, the principal organization of the neocortex is relatively u ...
