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Nanoparticle size influences the magnitude and quality of mucosal immune responses after intranasal immunization

Publications associées (42)

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Engineering nanoparticle-based vaccines: Implications for the quality of humoral and cellular immunity

Marcela Rincón-Restrepo

Vaccination is undoubtedly a major success in modern medicine. Yet, today there are pathogens for which no licensed or fully protective vaccines have been created. Development of vaccines based on subunit components has proven to be a safe and cost effecti ...

EPFL2016

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Nanoscale carrier platforms promote immune responses to vaccination by facilitating delivery of vaccine components to immunologically relevant sites. The technique is particularly valuable for subunit vaccination, in which coadministration of immunostimula ...

Amer Chemical Soc2016

Engineering the Extra Domain A of fibronectin as a vaccine adjuvant and study of its role in tissue regeneration

Ziad Julier

The extracellular matrix (ECM) protein fibronectin (FN) is a remarkably multifaceted molecule, including numerous fibronectin type III (FNIII) repeats carrying out different functions, which despite being extensively studied for over thirty years still pre ...

EPFL2016

Effective vaccine design and public vaccination programs have led to the eradication of several diseases and protected millions of people from deadly infections. However, intracellular infections remain a challenge and their eradication requires the activa ...

EPFL2016

NK Cells Respond to Haptens by the Activation of Calcium Permeable Plasma Membrane Channels

Horst Vogel, Horst Pick

Natural Killer (NK) cells mediate innate immunity to infected and transformed cells. Yet, NK cells can also mount hapten-specific recall responses thereby contributing to contact hypersensitivity (CHS). However, since NK cells lack antigen receptors that a ...

Public Library of Science2016

Silver nanoparticle-protein interactions in intact rainbow trout gill cells

Kristin Schirmer, Laura Sigg, Renata Behra, Yang Yue

Upon contact with biota, nanoparticles can bind to proteins, which coat the nanoparticles and form a nanoparticle-protein corona. Knowledge of corona proteins is therefore important for a mechanistic understanding of how nanoparticles interact with biomole ...

Royal Soc Chemistry2016

Antigen presentation is no longer the exclusive domain of cells of hematopoietic origin. Recent works have demonstrated that lymph node stromal cell (LNSC) populations, such as fibroblastic reticular cells, lymphatic and blood endothelial cells, not only p ...

Frontiers Media Sa2015

Emerging research on the roles of stromal cells in modulating adaptive immune responses has included a new focus on lymphatic endothelial cells (LECs). LECs are presumably the first cells that come into direct contact with peripheral antigens, cytokines, d ...

American Society for Clinical Investigation2014

Enhancement of hypersensitive transitions of rare-earth ions in the near field of nanoobjects

The change of intensities of optical transitions of atoms, molecules, and their ions in the near field of nanoobjects is of interest for researchers from both basic and applied points of view. The concept of a near field was used as early as the 1960s to s ...

Springer Verlag2014

Tunable T cell immunity towards a protein antigen using polymersomes vs. solid-core nanoparticles

Jeffrey Alan Hubbell, Melody Swartz, Armando Stano, Karen Dane

Using poly(propylene sulfide) (PPS) and poly(ethylene glycol) (PEG) as components of a nanocarrier platform, we sought to compare immune responses induced by PPS-bl-PEG polymersomes (PSs; watery-core structures, with antigen incorporated within the PSs) an ...

Elsevier Sci Ltd2013